Eukaryotic DNA is packaged into chromatin, folded and compacted. The building blocks of mammalian chromatin are nucleosomes, which consist of octomers of histone proteins that can be post-translationally modified (PTM). Protein phosphorylation is one of the most abundant PTMs. Histones are phosphorylated mainly on serine, threonine, tyrosine as well as other sites such as arginine, histidine an...