introduction : the aim of this study was to compare the cytotoxicity of mineral trioxide aggregate (mta) and a new endodontic cement (nec) on l929 mouse fibroblasts. materials and methods: different dilutions (neat, 1/2, 1/10, 1/100) of fresh and set materials placed adjacent flasks of l929 in dmem medium. cellular viability was assessed using mtt assay in three time intervals (24, 48, and 72 h...

essential oils, with plant origin, have been of special attention in cancer research during recent years. despite many reports on cytotoxic effects of plants from genus salvia, the potential application of their extracts in cancer therapy remains to be assessed in more precise and detailed examinations on the main cause of such effects. in this research, the cytotoxic effect and anticancer acti...

The extent of coordinate control over the multiple initiation events in DNA replication has been investigated in three mammalian cell lines by DNA fiber autoradiography. Quantitative estimates have been obtained of the degree of synchrony among initiations occurring on stretches of DNA. Synchrony decreases markedly with increasing distance between initiation sites in MDBK (bovine) and L929 (mou...

Damage to DNA caused by exposure of L929 fibroblasts to ozone was reflected by the generation of strand breaks, DNA inter-strand cross-links and DNA-protein cross-links. Addition of propan-2-ol, a hydroxyl radical scavenger, did not affect the formation of strand breaks. In model experiments it appeared that both purines and pyrimidines were involved in DNA inter-strand and DNA-protein cross-li...

In the course of structure-activity relationship studies, diversely substituted 1-(beta-D-glucopyranosyl)-isoindigo derivatives were prepared from commercially available indolines. Their antiproliferative activities were evaluated toward a panel of human solid cancer cell lines (PC 3, DLD-1, MCF-7, M4Beu, A549, PA 1), a murine cell line (L929) and a human fibroblast primary culture to get an in...