Neste artigo são apresentadas a síntese e a caracterização de dois compostos binucleares de ferro, os quais contêm uma ponte m-oxo. Os compostos [(SO 4 )(L5)Fe(m-O)Fe(L5)(SO 4 )]•6H 2 O, 1, e [Cl(L5)Fe(m-O)Fe(L5)Cl]Cl 2 •2H 2 O, 2, foram obtidos nas reações entre 1-(bis-piridin-2-ilmetilamino)-3-cloropropan-2-ol (L5) e os sais FeSO 4 •7H 2 O e FeCl 3 •6H 2 O, respectivamente. Os espectros eletr...

STUDY DESIGN A systematic review. OBJECTIVE The objective of this study was to determine the safety and efficacy of stand-alone anterior lumbar interbody fusion (sa-ALIF) for the treatment of symptomatic isthmic spondylolisthesis of L5-S1 by assessing the level of available clinical and radiographic evidence. METHODS A systematic review utilizing Medline, Embase, and Scopus online databases...

Tissue-specific detargeting by miRNAs has been demonstrated to be a potent strategy to restrict adenoviral replication to cancer cells. These studies have generated adenoviruses with miRNA target sites placed in the 3'UTR of early gene products. In this work, we have studied the feasibility of providing tissue-specific selectivity to replication-competent adenoviruses through the regulation of ...

Diazepam binds with the same high affinity to the central benzodiazepine receptor (CBR) and the peripheral benzodiazepine receptor, which has been renamed translocator protein (TSPO). Both receptors could promote neurosteroid synthesis. In the present study, we investigated whether a single dose of diazepam could inhibit neuropathic pain induced by L5 spinal nerve ligation (L5 SNL), and whether...

The spine of L4 usually lies on a line drawn between the highest points of the iliac crests (Tuffier's line) in adults. Although its accuracy has been questioned, it is still commonly used to identify the spinous process of the 4th lumbar vertebra before performing lumbar neuraxial procedures. In children, this line is said to cross the midline at the level of L5. A literature search revealed t...

A biomechanical evaluation of the job-related stresses imposed upon a worker is a potential means of reducing the high incidence rates of manual material handling injuries in industry. A biomechanical model consisting of seven rigid links joined at six articulations has been developed for this purpose. Using data from cinematographic analysis of lifting motions the model calculates: (1) body po...

PURPOSE Many factors such as lumbar instability and spinopelvic alignment are associated with low back pain. Our purpose was to analyze the pelvic incidence - one of spinopelvic alignment parameters- and spine instability correlations in patients with chronic low back pain. METHODS Fifty-two patients suffering from chronic low back pain entered this case control study. Lateral spine radiograp...

BACKGROUND Reactive oxygen and nitrogen species are key molecules that mediate neuropathic pain. Although hydrogen is an established antioxidant, its effect on chronic pain has not been characterized. This study was to investigate the efficacy and mechanisms of hydrogen-rich normal saline induced analgesia. METHODOLOGY/PRINCIPAL FINDINGS In a rat model of neuropathic pain induced by L5 spinal...

Hyperpolarization-activated, cyclic nucleotide-gated, nonspecific cation (HCN) channels have a well-characterized role in regulation of cellular excitability and network activity. The role of these channels in control of epileptiform discharges is less thoroughly understood. This is especially pertinent given the altered HCN channel expression in epilepsy. We hypothesized that inhibition of HCN...

BACKGROUND AND PURPOSE The dorsal root ganglion (DRG) of the spinal nerve has been considered a key structure in the mechanism of low-back pain and radicular symptoms. The purpose of this study was to clarify the normal morphologic features and variations of the lumbar DRGs in a healthy population by using 3D MR imaging. METHODS 3D fast-field echo (FFE) with water selective excitation coronal...