Methylmercury (MeHg) readily crosses cell membrane barriers to reach its target tissue, the brain. Although it is generally assumed that this rapid transport is due to simple diffusion, recent studies have demonstrated that MeHg is transported as a hydrophilic complex, and possibly as an L-cysteine complex on the ubiquitous L-type large neutral amino acid transporters (LATs). To test this hypot...

Nitric oxide (NO) contributes to hypoxia-induced pial artery dilation, at least in part, through the formation of cGMP and the subsequent release of methionine enkephalin and leucine enkephalin in the newborn pig. In separate studies, these opioids also were observed to elicit NO-dependent pial artery dilation, whereas light/dye endothelial injury reduced hypoxic pial dilation. The current stud...

The methionine salvage pathway is responsible for regenerating methionine from its derivative, methylthioadenosine. The complete set of enzymes of the methionine pathway has been previously described in bacteria. Despite its importance, the pathway has only been fully described in one eukaryotic organism, yeast. Here we use a computational approach to identify the enzymes of the methionine salv...

A Cu(II) complex of the amino acid L-selenomethionine of stoichiometry Cu(L-SeMet)2, has been prepared and characterized. Crystallographic data were obtained by means of X-ray powder diffractometry and showed that the compound is isostructural with the related complex of L-methionine, Cu(L-Met)2. The structural analogy is also supported by the analysis of the IR and Raman spectra of the complex...

essential amino acids such as methionine have been increasingly included into diets of lambs. however, few studies have determined the effects of methionine supplementation in the general performance and economic returns of lamb production. to address this question, 21weaned male rahmani lambs were allotted to 3 dietary treatments: control diet (c), control diet plus 3.30 g of methionine/kg con...

In a previous study (l), nn-methionine was shown to be a competitive inhibitor of the uptake of glycine by Ehrlich ascites cells. The results obtained, however, could not give any indication as to whether glycine and methionine are transported by the same or different systems. This problem has recently been the object of further consideration by Paine and Heinz (a), who were also unable to prov...

Perfusion of isolated rat heart with L-methionine produced a positive inotropic effect that was temporally preceded, as well as accompanied, by an increase of methyl group incorporation into N-methylated phospholipids of the myocardium. Maximal increase in contractile force development was associated with maximal methyl group incorporation. Both parameters showed a dose-related dependence on me...

Effects on wool growth rate of abomasal supplements of several amino acids (glycine, glutamic acid, arginine, lysine, and threonine) and of some sulphurcontaining compounds (L-cysteamine, sulphuric acid, and methionine hydroxy analogue) were examined. None of the abomasal supplements, apart from methionine hydroxy analogue, was effective for stimulating wool growth. Methionine hydroxy analogue ...

Six experiments were conducted with newly weaned pigs (8 kg) to evaluate the effects of 4% excesses of DL-methionine, L-tryptophan, L-threonine, L-lysine or L-arginine on growth or "choice" (i.e., self-selection) when added to 20% protein, corn-soybean meal (C-SBM) diets. Arginine was supplied as the free base and lysine as lysine acetate to avoid acid-base problems. In the growth study, gain w...

Methionine-dependence phenotype (MDP) refers to the reduced ability of cells to proliferate when methionine is restricted and/or replaced by its immediate precursor homocysteine. MDP is a characteristic of human tumors in vivo, human tumor cell lines, and normal somatic tissue in some individuals. It was hypothesized that MDP is a risk factor for developing breast cancer in BRCA (BRCA1 and BRCA...