1 Institute of Mathematics for Industry, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan. 2 Research Institute for Electronics Science, Hokkaido University, N12W7, Kita-Ward, Sapporo, 060-0812, Japan. 3 Research Institute of Electrical Communication, Tohoku University, 2-1-1, Katahira, Aoba-ku, Sendai 980-8577, Japan. 4 Japan Science and Technology Agency CREST, 7 Goban-cho, C...

1Department of Pathology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan 2Global Scientific Information and Computing Center, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan 3Medical Solutions Division, NEC Corporation, 7-1, Shiba 5-chome, Minato-ku, Tokyo 108-001, Japan 4Department of Gastroenterology and Hepatology, Mus...

* contact author Human Genome Center, Institute of Medical Science, University of Tokyo 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan {imoto, takao, miyano}@ims.u-tokyo.ac.jp The Institute of Statistical Mathematics, 4-6-7, Minami-Azabu, Minato-ku, Tokyo, 106-8569, Japan [email protected] Graduate School of Genetic Resources Technology, Kyushu University 6-10-1 Hakozaki, Higashi-ku, Fuk...

Hidenobu Senpuku*, Akio Tadal, Masanari Takada2, Tsutomu Sato2 and Nobuhiro Hanada3 Department ofBacterioloBy, National Institute ofInfectious Diseases, and 3Department of Oral Health, National Institute of Public Health, 7Toyama 1-23-1, Shinjuku-ku, 7Tolg)0 1 62-8640, JChiba Cio; Health Center: Saiwai 1-3-9, Mihama-ku, Chiba 261-8755 and 2Department of Preventive and CommunityDentist77), Nl'pp...

Satoru Mimura, Makiko Komata, Tsutomu Kishi, Katsuhiko Shirahige and Takumi Kamura* Division of Biological Science, Graduate school of Science, Nagoya University Chikusa-ku, Nagoya, Japan, Division for Gene Research, Center for Biological Resources and Informatics, Tokyo Institute of Technology, Nagatsuta, Midori-ku, Yokohama City, Kanagawa, Japan, Kishi Initiative Research Unit, RIKEN, Hirosaw...

Ku proteins are associated with a variety of cellular processes such as repair of DNA-double-strand breaks, telomere maintenance and retrotransposition. In recent years, we have learned a lot about their cellular and molecular functions and it has turned out that Ku-dependent processes affect the stability of the genome, both positively and negatively, in several ways. This article gives an ove...

The serine/threonine protein kinase ATM signals to cell cycle and DNA repair components by phosphorylating downstream targets such as p53, CHK2, NBS1, and BRCA1. Mutation of ATM occurs in the human autosomal recessive disorder ataxia-telangiectasia, which is characterized by hypersensitivity to ionizing radiation and a failure of cells to arrest the cell cycle after the induction of DNA double-...

PURPOSE The purpose of this study was to evaluate the utility of specific IgE (sIgE) concentrations for the diagnosis of immediate-type egg and cow's milk (CM) allergies in Korean children and to determine the optimal cutoff levels. METHODS In this prospective study, children ≥12 months of age with suspected egg or CM allergy were enrolled. Food allergy was diagnosed by an open oral food chal...

Steinernemacarpocapsae is a nematode pathogenic in a wide variety of insect species. The great pathogenicity of this nematode has been ascribed to its ability to overcome the host immune response; however, little is known about the mechanisms involved in this process. The analysis of an expressed sequence tags (EST) library in the nematode during the infective phase was performed and a highly a...

Cell death linked to oxidative DNA damage has been implicated in acute pancreatitis. The severe DNA damage, which is beyond the capacity of the DNA repair proteins, triggers apoptosis. It has been hypothesized that oxidative stress may induce a decrease in the Ku70 and Ku80 levels and apoptosis in pancreatic acinar cells. In this study, it was found that oxidative stress caused by glucose oxida...