Hexanucleotide repeat expansion in the bi-directionally transcribed C9orf72 gene is the most frequent cause of familial ALS and frontotemporal dementia (FTD). Kramer et al. (2016) report in Science that targeted reduction in the transcription elongation factor SUPT4H1/SUPT5H reduces both sense and antisense repeat-containing RNAs and their associated neurodegeneration.

Karl R. B. Schmitt, Elise A. Larsen, Matthew Miller, Abdel-Hameed A. Badawy, Mara Dougherty, Artesha Taylor Sharma, Katie Hrapczynski, Andrea Andrew, Breanne Robertson, Alexis Williams, Sabrina Kramer, and Spencer Benson* University of Maryland, Center for Teaching Excellence, College Park, MD 20742, Arkansas Tech University, Russellville, AR 72801, University of Macau, Centre for Teaching and ...

R.B.G. Kramer, A.V. Silhanek, W. Gillijns, and V.V. Moshchalkov INPAC, Institute for Nanoscale Physics and Chemistry, Nanoscale Superconductivity and Magnetism Group, K.U. Leuven, Celestijnenlaan 200D, B–3001 Leuven, Belgium Institut Néel, CNRS, Université Joseph Fourier, BP 166, 38042 Grenoble Cedex 9, France Département de Physique, Université de Liège, B4000 Liège, Belgium (Received 20 May 2...

Title: Barriers and Facilitators to Implementation of VA Home-Based Primary Care on American Indian Reservations: A Qualitative Multi-case Study Authors: B. Josea Kramer ([email protected]) Sarah Cote ([email protected]) Diane Lee ([email protected]) Beth Creekmur ([email protected]) Debra Saliba ([email protected]) Version: 1 Date: 05 Jul 2017 Author’s response to reviews: July 5, 2017 An...

Marian Knight ([email protected]) Cynthia Berg ([email protected]) Peter Brocklehurst ([email protected]) Michael Kramer ([email protected]) Gwyneth Lewis ([email protected]) Jeremy Oats ([email protected]) Christine L Roberts ([email protected]) Cathy Spong ([email protected]) Elizabeth Sullivan ([email protected]) Jos van Roosmalen...

Bu çalışmada sinemada modern aile filmlerinin öncüsü olarak kabul edilen Kramer vs. (Kramer Kramer’e Karşı, Robert Benton, 1979) ve kırk yıl sonra benzeri bir hikâyeyi yeniden üreten Marriage Story (Evlilik Hikayesi, Noah Baumbach, 2019) filmleri, feminist perspektif çerçevesinde analiz edilmiştir. Geçen zamana bağlı pek çok alanda büyük toplumsal dönüşümler yaşanmasına rağmen sinemasal anlatı ...

Carbohydrate-Electrolyte Solution During Military Training: Effects on Physical Performance, Mood State and Immune Function by CPT Scott J. Montain, Ph.D., MAJ Ronald L Shippee, Ph.D. and William J.Tharion, M.S. U.S. Army Research Institute of Environmental Medicine Natick, MA 01760-5007 and Tim R. Kramer, Ph.D., Beltsville Human Nutrition Research Center U.S. Department of Agriculture Beltsvil...

Since Kramer (1933) investigated the optical properties ofhemoglobin/oxyhemoglobin solutions, many methods have been proposed for the photometric estimation of the oxygen saturation of blood. A new method can only be advocated if it offers economy of apparatus or reagents, greater ease of performance, or the elimination of sources of error. It is upon these grounds that the following method is ...

Theodore M. Bartoletti,* Skyler L. Jackman,* Norbert Babai, Aaron J. Mercer, Richard H. Kramer, and Wallace B. Thoreson Department of Ophthalmology and Visual Sciences and Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska; Department of Neurobiology, Harvard Medical School, Boston, Massachusetts; and Department of Molecular and Cell...

Abstract This paper is devoted to the establishment of two-dimensional sampling theorems for discrete transforms, whose kernels arise from second order partial difference equations. We define a type operator and investigate its spectral properties. Green’s function constructed that generate orthonormal basis eigenvectors are defined. A Kramer-type lemma introduced two Lagrange interpolation pro...