Rab3A, Rab3B, Rab3C, and Rab3D are closely related GTP-binding proteins of synaptic vesicles that may function in neurotransmitter release. We have produced knock-out (KO) mice for Rab3B and Rab3C and crossed them with previously generated Rab3A and 3D knock-out mice to generate double, triple, and quadruple Rab3 knock-out mice. We have found that all single and double Rab3 knock-out mice are v...

University Higher School of Economics (HSE). Any opinions or claims contained in this Working Paper do not necessarily reflect the views of HSE What is the optimal way to seed a knockout tournament in order to maximize the overall spectator interest in it? Seeding affects the set of matches being played in the tournament, while neutral spectators tend to prefer to watch (i) close and intense ma...

We study parallel knock-out schemes for graphs. These schemes proceed in rounds in each of which each surviving vertex simultaneously eliminates one of its surviving neighbours; a graph is reducible if such a scheme can eliminate every vertex in the graph. We resolve the square-root conjecture, first posed at MFCS 2004, by showing that for a reducible graph G, the minimum number of required rou...

Mice lacking a functional vasopressin 1b receptor (Avpr1b) display decreased levels of aggression and social memory. Here, we used Avpr1b-knock-out (Avpr1b(-/-)) mice to examine whether an abnormality of this receptor results in specific cognitive deficits in the domain of hippocampal function. Avpr1b(-/-) mice were deficient in sociability and in detecting social novelty, extending previous fi...

Narcolepsy is caused by a lack of orexin (hypocretin), but the physiologic process that underlies the sleepiness of narcolepsy is unknown. Using orexin knock-out (KO) mice as a model of narcolepsy, we critically tested the three leading hypotheses: poor circadian control of sleep and wakefulness, inadequate activation of arousal regions, or abnormal sleep homeostasis. Compared with wild-type (W...