OBJECTIVE To assess the relief of migraine pain, especially in the acute phase, by comparing active treatment, ie, kinetic oscillation stimulation (KOS) in the nasal cavity, with placebo. BACKGROUND Exploratory trials testing the efficacy of KOS on migraine patients indicated that this treatment could be a fast-acting remedy for acute migraine pain. METHOD Thirty-six patients were randomize...

The existence of an in-frame deletion mutant correlates with the sensitivity of lung cancers to EGFR (epidermal growth factor receptor)-targeted tyrosine kinase inhibitors. We reported previously that the in-frame 15-bp deletional mutation (delE746-A750 type deletion) was constitutively active in cells. Kinetic parameters are important for characterizing an enzyme; however, it remains unclear w...

The role of phosphorylation in the regulation of rabbit muscle phosphofructokinase was investigated by monitoring the effect of this covalent modification on the steady-state kinetics and complex formation between F-actin and the enzyme. Binding of phosphofructokinase to F-actin at pH 7.0 and 23 degrees C was monitored by sedimentation. These experiments show that phosphorylated phosphofructoki...

Phosphocreatine (PCr) depletion during isometric twitch stimulation at 5 Hz was measured by (31)P-NMR spectroscopy in gastrocnemius muscles of pentobarbital-anesthetized MM creatine kinase knockout (MMKO) vs. wild-type C57B (WT) mice. PCr depletion after 2 s of stimulation, estimated from the difference between spectra gated to times 200 ms and 140 s after 2-s bursts of contractions, was 2.2 +/...

the kinetic of photo oxidative decolorization of c.i. acid yellow 23 (ay23) was investigated in uv/ process. the semi-logarithmic of the concentrations of ay23 versus irradiation time were linear, suggesting pseudo-first order reaction. a simple kinetic model is proposed which confirms pseudo- first order reaction. the results indicate that the apparent reaction rate constant is a function of l...

How cells convert the duration of signals into differential adaptation of gene expression is a poorly understood issue. Signal-induced immediate-early gene (IEG) expression couples early signals to late expression of downstream genes. Here we study how kinetic features of the IEG- system allow temporal integration of stimuli in a pancreatic beta cell model of metabolic stimulat...

phenol and its homologues are aromatics containing hydroxyl, methyl, amide and sulphonic groups attached to the benzene ring. these molecules are both anthropogenic and xenobiotics. phenols are environmental pollutants discharged through wastewaters from various industries. phenols are toxic to several biochemical reactions. however biological transformation of phenols to non-toxic entities exi...

in this work, styrene removal from wastewater by using sugarcane waste (bagasse) as an adsorbent was studied. equilibrium isotherms and kinetics were determined; the effects of bagasse particle size and concentration, solutions ph, and temperature on the biosorption of styrene were studied in batch experiments. adsorption equilibrium data was successfully fitted to langmuir isotherms (r2=0.986)...

Flubendiamide, developed by Nihon Nohyaku Co., Ltd. (Tokyo, Japan), is a novel activator of ryanodine-sensitive calcium release channels (ryanodine receptors; RyRs), and is known to stabilize insect RyRs in an open state in a species-specific manner and to desensitize the calcium dependence of channel activity. In this study, using flubendiamide as an experimental tool, we examined an impact of...