Traditional diagnosis of acute kidney injury (AKI) depends on detection of oliguria and rise of serum creatinine level, which is an unreliable and delayed marker of kidney damage. Delayed diagnosis of AKI in the critically ill patient is related to increased morbidity and mortality, prolonged length of stay, and cost escalation. The discovery of a reliable biomarker for early diagnosis of AKI w...

Expression of kidney injury molecule-1 (Kim-1) is rapidly upregulated following tubular injury, constituting a biomarker for acute kidney damage. We examined the renal localization of Kim-1 expression in PKD/Mhm (polycystic kidney disease, Mannheim) (cy/+) rats (cy: mutated allel, +: wild type allel), an established model for autosomal dominant polycystic kidney disease, with chronic, mainly pr...

BACKGROUND Whether injury-related molecules in urines of individuals with ischemia-reperfusion injury (IRI) are independent predictors of graft outcomes and provide additional information compared with usual risk factors remains to be established. METHODS We explored a cohort of 244 kidney transplant recipients who systematically had a urine collection 10 days after transplantation. The injur...

The aim of this study was to assess the integrity and kidney overall functional capacity subjects exposed landfill emissions. Urine blood levels Pb Cd, several newly biomarkers nephrotoxicity (Kim Injury Molecule 1 (KIM-1), alpha-1 Microglobulin (α1 M), beta-2 (β2 Cystatin-C (Cyst C), Clusterin, alpha-glutathione S-transferase (GSTα), pi-glutathione (GSTπ), Tissue Inhibitor Metalloproteinase-1 ...

Abstract Acute kidney injury (AKI) is morphologically characterized by a synchronized plasma membrane rupture of cells in specific section nephron, referred to as acute tubular necrosis (ATN). Whereas the involvement necroptosis well characterized, genetic evidence supporting contribution ferroptosis lacking. Here, we demonstrate that loss suppressor protein 1 ( Fsp1 ) or targeted manipulation ...

Kidney injury molecule 1 (KIM-1, also known as TIM-1) is markedly upregulated in the proximal tubule after injury and is maladaptive when chronically expressed. Here, we determined that early in the injury process, however, KIM-1 expression is antiinflammatory due to its mediation of phagocytic processes in tubule cells. Using various models of acute kidney injury (AKI) and mice expressing muta...

Rhabdomyolysis is a life-threatening condition caused by skeletal muscle damage with acute kidney injury being the main complication dramatically worsening prognosis. Specific treatment for rhabdomyolysis-induced lacking and mechanisms of are unclear. To clarify this, we studied intra-kidney complement activation (C3d C5b-9 deposits) in tubules vessels patients mice injury. The lectin pathway w...

Acute kidney injury (AKI) is common and urgently requires new preventative therapies. Expression of a cyclin-dependent kinase (CDK) inhibitor transgene protects against AKI, suggesting that manipulating the tubular epithelial cell cycle may be a viable therapeutic strategy. Broad spectrum small molecule CDK inhibitors are protective in some kidney injury models, but these have toxicities and ep...

Nucleotide-binding oligomerization domain (Nod) 1 and Nod2 are members of a family of intracellular innate sensors that participate in innate immune responses to pathogens and molecules released during the course of tissue injury, including injury induced by ischemia. Ischemic injury to the kidney is characterized by renal tubular epithelial apoptosis and inflammation. Among the best studied in...