Human immunodeficiency virus type 1 (HIV-1) causes a persistent viral infection resulting in the demise of immune regulatory cells. Clearance HIV-1 results integration proviral DNA into genome host cells, which provides means for evasion and long-term persistence. A therapeutic compound that specifically targets sustainably activates latent provirus could be transformative is goal “shock-and-ki...

This review paper assesses the status and findings of 100% renewable energy (RE) system analyses for Africa published in scientific journals. The RE topic is rarely researched with regard to Africa; only 54 peer-reviewed articles exist entire continent, which about 7% global total (750 articles) while reflecting almost a quarter world population by 2050. As comparison, more 5.9 million inhabita...

Rotational energy has been a key element in many domestic and industrial areas from wristwatches to offshore wind turbines. It utilized on large scale megawatt-scale hydraulic power generators kilowatt-scale vehicles rotating machines, watt-scale hand-held tools, milliwatt (microwatt) rotational harvesters. The scope of this review is microwatt-level harvesters (millimeter centimeter size) that...

In August 1861 the London-based newspaper The Times published world’s first “daily weather forecast.” term itself was created by enterprising meteorologist Robert FitzRoy, who wanted to distance his work from astrological “prognostications.” That story has led a widespread assumption that forecasting is an entirely modern phenomenon and in earlier periods only quackery or folklore-based signs w...

•Numerous SARS-CoV-2 proteins synergize to suppress immune sensing and signaling•Nsp14 targets IFNAR1 for lysosomal degradation•ORF3a ORF7a block autophagy by different mechanisms•Synergistic treatment with IFN-γ -λ1 is highly effective against Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades most innate responses but may still be vulnerable some. Here, we systematically anal...

Nuclei are at the heart of all palpable matter.11. National Research Council, Nuclear Physics: Exploring Heart Matter, Academies Press (2013). Although we understand properties things touch every day—from carbon in our bodies to lanthanum cell phones—so much more may be revealed by investigating elements limits their stability. Those become apparent when too many neutrons or protons added a nuc...

•Artificial intelligence identifies HSV- and AdV-infected cells without specific probes.•Imaging lytic-infected reveals nuclear envelope rupture AdV dissemination.•Live cell imaging neural networks presciently pinpoint cells.•Lytic-infected nuclei have mechanical properties distinct from non-lytic nuclei. Imaging across scales disease mechanisms in organisms, tissues, cells. Yet, particular inf...

How does violent military coercion work alongside liberal democratic values in contemporary iterations of imperialism? This article shows how the less-than-lethal paradigm occludes death and perpetuates extreme forms both deadly not-deadly Iraq. Key to 2003 invasion subsequent counterinsurgency Iraq, extends across doctrine US popular discourse. Based on idea that killing is an undesirable way ...

Na,K-ATPase is essential for the regulation of cytoplasmic Na and K levels in lens cells. Studies on the intact lens suggest activation of tyrosine kinases may inhibit Na,KATPase function. Here, we tested the influence of Lyn kinase, a Src-family member, on tyrosine phosphorylation and Na,K-ATPase activity in membrane material isolated from porcine lens epithelium. Western blot studies indicate...