Introduction: Iron plays an important role in myelination. Ferritin is a reliable indicator of the tissue iron store and umbilical cord ferritin level reflects the in utero iron stores. Objective is to study the effect of the umbilical cord ferritin level on the ABR recording in the newborn.   Materials and Methods: The study was conducted in a ...

Background: the suppression effect with contralateral white noise observed in the brainstem auditory evoked potential can be influenced by the efferent auditory system. Aim: to evaluate the suppression effect with contralateral white noise in the Brainstem Auditory Evoked Potential of individuals with normal hearing. Methods: 25 individuals, ranging in age from 18 to 30 years, of both genders, ...

The increasing use of mobile communication has triggered an interest in its possible effects on the regulation of neurotransmitter signals. Due to the close proximity of mobile phones to hearing-related brain regions during usage, its use may lead to a decrease in the ability to segregate sounds, leading to serious auditory dysfunction caused by the prolonged exposure to radiofrequency (RF) rad...

Objective: To evaluate the frequency of hearing impairment and prenatal, antenatal, postnatal variables associated with in neonates at Indus hospital Karachi. Study Design: Prospective, Observational, Cohort study. Setting: Department Pediatrics Neonatology, Sheikh Saeed Memorial Campus (SSMC) Hospital Health Network (IHHN) Karachi, Pakistan. Period: July 2020 to June 2022. Material & Metho...

OBJECTIVES This study investigated whether neurophysiologic responses (auditory evoked potentials) differ between typically developed children and children with phonological disorders and whether these responses are modified in children with phonological disorders after speech therapy. METHODS The participants included 24 typically developing children (Control Group, mean age: eight years and...

Auditory deviance detection has been associated with a human auditory-evoked potential (AEP), the mismatch negativity, generated in the auditory cortex 100-200 ms from sound change onset. Yet, single-unit recordings in animals suggest much earlier (∼20-40 ms), and anatomically lower (i.e., thalamus and midbrain) deviance detection. In humans, recordings of the scalp middle-latency AEPs have con...

RESULTS: On the first day of exposure to the stimulus, the auditory brainstem response thresholds were lower in the treatment group than in the control and prevention groups. After 3-day recovery, the prevention group showed a greater auditory brainstem response threshold shift than the other two groups. The expression of caspase-3 in hair cells and stria vascularis cells was weaker in the trea...

Background: Lead is a major environmental pollutant and can adversely affect humans and animals. There are conflicting data about the ototoxic effect of lead. This study experimentally examined the association between blood lead levels (BLL) and the subsequent hearing impairment in male rats. Methods: Twenty-two male rats were randomly categorized into experimental (exposed to lead acetate, ...

To make sense of complex auditory scenes, the auditory system sequentially organizes auditory components into perceptual objects or streams. In the conventional view of this process, the cortex plays a major role in perceptual organization, and subcortical mechanisms merely provide the cortex with acoustical features. Here, we show that the neural activities of the brainstem are linked to perce...

Cochlear synaptopathy (or hidden hearing loss), due to noise exposure or aging, has been demonstrated in animal models using histological techniques. However, diagnosis of the condition in individual humans is problematic because of (a) test reliability and (b) lack of a gold standard validation measure. Wave I of the transient-evoked auditory brainstem response is a noninvasive electrophysiolo...