Chronic stable asthma is characterized by inflammation of the airway wall, with abnormal accumulation of basophils, eosinophils, lymphocytes, mast cells, macrophages, dendritic cells, and myofibroblasts. Airway inflammation is not limited to severe asthma, but is also found in mild and moderate asthma. This inflammation results in a peculiar type of lymphocytic infiltration whereby Th2 lymphocy...

BACKGROUND Bronchial asthma is a chronic airway inflammatory disease that involves T lymphocytes. METHODS In order to explore the effect of Lactobacillus salivarius on Th1/Th2 cytokines and the number of spleen CD4(+) CD25(+) Foxp3(+) Treg in asthma Balb/c mouse, we constructed acute asthma model with ovalbumin to observe the mouse behavior change in Balb/c mice. The expression of GATA-3 mRNA...

Gastroesophageal reflux disease (GERD) is clearly explained as the unintentional passage of stomach contents through the esophagus that takes place many times during the day both in children and in adults. GERD leads to symptoms of heartburn and regurgitation, these defined esophageal symptoms are in dichotomy with extraesophageal symptoms of GERD. These extra-esophageal symptoms include severa...

Key words: fibromuscular dysplasia; histology; hyper-and urea 395 mmol/l. The urinary sediment showed microscopic haematuria and proteinuria (dip stick tension; kidney; pathology; renal artery +++). The patient was immediately placed on haemodialysis and aggressive ultrafiltration. The further work-up included an abdominal ultrasound and

BACKGROUND The role of Th2 cells (producing interleukin (IL-)4, IL-5 and IL-13) in allergic asthma is well-defined. A distinct proinflammatory T cell lineage has recently been identified, called Th17 cells, producing IL-17A, a cytokine that induces CXCL8 (IL-8) and recruits neutrophils. Neutrophilic infiltration in the airways is prominent in severe asthma exacerbations and may contribute to ai...

BACKGROUND House dust mite (HDM) allergens have been reported to increase airway epithelial permeability, thereby facilitating access of allergens and allergic sensitisation. OBJECTIVES The authors aimed to understand which biochemical properties of HDM are critical for epithelial immune and barrier responses as well as T helper 2-driven experimental asthma in vivo. METHODS Three commercial...

Telocytes (TCs) newly discovered as the mesenchyme-derived interstitial cells were found to have supportive effects on mesenchymal stem cells (MSCs). The present study aimed at investigating effects of TCs or TCs gathered with MSCs on experimental airway inflammation and hyper-responsiveness. The TCs were isolated from the lung tissue of the female BALB/c mice. The ovalbumin (OVA)-induced asthm...