نتایج جستجو برای: ketotifen fumarate

تعداد نتایج: 7851  

2012
Guoqiang Xu Liming Liu Jian Chen

BACKGROUND Fumaric acid is a commercially important component of foodstuffs, pharmaceuticals and industrial materials, yet the current methods of production are unsustainable and ecologically destructive. RESULTS In this study, the fumarate biosynthetic pathway involving reductive reactions of the tricarboxylic acid cycle was exogenously introduced in S. cerevisiae by a series of simple genet...

Journal: :Inflammatory bowel diseases 2005
Kari Erichsen Anne Marita Milde Gülen Arslan Lars Helgeland Oddrun Anita Gudbrandsen Rune J Ulvik Rolf K Berge Trygve Hausken Arnold Berstad

BACKGROUND Oral ferrous iron therapy may reinforce intestinal inflammation. One possible mechanism is by catalyzing the production of reactive oxygen species. We studied the effects of low-dose oral ferrous fumarate on intestinal inflammation and plasma redox status in dextran sulfate sodium (DSS)-induced colitis in rats. METHODS Forty male Wistar rats were divided into 5 groups: no intervent...

Journal: :Biochimica et biophysica acta 2012
Chika Sakai Eriko Tomitsuka Hiroyasu Esumi Shigeharu Harada Kiyoshi Kita

Recent research on respiratory chain of the parasitic helminth, Ascaris suum has shown that the mitochondrial NADH-fumarate reductase system (fumarate respiration), which is composed of complex I (NADH-rhodoquinone reductase), rhodoquinone and complex II (rhodoquinol-fumarate reductase) plays an important role in the anaerobic energy metabolism of adult parasites inhabiting hosts. The enzymes i...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2009
Ferdia A Gallagher Mikko I Kettunen De-En Hu Pernille R Jensen René In 't Zandt Magnus Karlsson Anna Gisselsson Sarah K Nelson Timothy H Witney Sarah E Bohndiek Georg Hansson Torben Peitersen Mathilde H Lerche Kevin M Brindle

Dynamic nuclear polarization of (13)C-labeled cell substrates has been shown to massively increase their sensitivity to detection in NMR experiments. The sensitivity gain is sufficiently large that if these polarized molecules are injected intravenously, their spatial distribution and subsequent conversion into other cell metabolites can be imaged. We have used this method to image the conversi...

Journal: :British Journal of Clinical Pharmacology 1981

2008
N Toplak V Glavnik M Kuhar T Avcin

Background The pathogenesis of PFAPA syndrome is unknown. According to Stojanov et al. cytokine profile in PFAPA syndrome suggests Th1 mediated inflammatory process resulting in continuous inflammation and reduced Th2 anti-inflammatory response. Interferon γ might be responsible for suppressing the production of IL-4 and IL10. Hung et al. showed suppressive effects of ketotifen on the expressio...

Journal: :The Journal of biological chemistry 1996
K Wimalasena S Dharmasena D S Wimalasena D K Hughbanks-Wheaton

The interactions of reductants with dopamine beta-monooxygenase (DbetaM) were examined using two novel classes of reductants. The steady-state kinetics of the previously characterized DbetaM reductant, N,N-dimethyl-1,4-p-phenylenediamine (DMPD), were parallel to the ascorbic acid-supported reaction with respect to pH dependence and fumarate activation. DMPD also displayed pH and fumarate-depend...

Journal: :Multica Science and Technology 2022

Inventory has a very important role in increasing sales and service to consumers. The purpose of this study was determine the information patterns form association rules at certain period that can provide advice pharmacy managing drug inventory. algorithm used is priori results rules. Association are obtained by implementing an apriori data mining website-based system using laravel resulting ca...

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