introduction: mineral trioxide aggregate (mta) is an endodontic material with different clinical applications e.g. root-end filling, pulp capping and perforation repair.  it has been reported to possess antimicrobial and antifungal activities. the aim of this study was to examine the effect of white mta on formalin-induced hyperalgesia in a rat with inflammatory pain. materials and methods: inf...

The immune system can influence social motivation with potentially dire consequences for group-housed production animals, such as pigs. aim of this study was to test the effect a controlled activation in pigs, through an injection lipopolysaccharide ( LPS ) and intervention ketoprofen on centrality parameters at individual level. In addition, we wanted time relative general network order get be...

The occurrence of pharmaceuticals in the aqueous environment has been widely published but the fate of pharmaceutical residues in the environment continues to attract the attention of the scientific community. Due to the widespread use of non-steroidal anti-inflammatory drugs (NSAIDs), this group of drugs is often detected and determined in surface waters, influent and effluent wastewaters, and...

The aim of the present study is to formulate and investigate the potential of nanoemulsion formulation for topical delivery of ketoprofen. In this study, Palm Oil Esters (POEs) a newly introduced oil by Universiti Putra Malaysia researchers was chosen for the oil phase of the nanoemulsion, because the oil was reported to be a good vehicle for pharmaceutical use. Oil-in-water nanoemulsion was pr...

Alginate-metal complexes were prepared with divalent (Ca, Ba, Zn) and trivalent metals (Fe, Al) via congealing method in form of beads. Alginate mixed metals (Ca & Fe) complexes were also prepared by simultaneous and consecutive congealing. The studied beads were blank beads and racemic ketoprofen (KTP) loaded beads. Metal content was determined by atomic absorption spectroscopy and was 1.8% to...

Abstract Ketoprofen (K) belongs to the family of nonsteroidal anti-inflammatory drugs (NSAIDs) and demonstrates analgesic, antipyretic properties. K is one most commonly used NSAIDs because speed effectiveness its activity. currently for treatment pain symptoms in rheumatic diseases, however, many researchers are looking new uses K. The aim review was present possible applications as indicated ...

The protein binding of non-steroidal anti-inflammatory drugs flurbiprofen, ketoprofen and etodolac with human serum albumin (HSA) was investigated using indirect chiral high performance liquid chromatography (HPLC) and ultrafiltration techniques. S-(-)-1-(1-naphthyl)-ethylamine (S-NEA) was utilized as chiral derivatization reagent and pre-column derivatization RP-HPLC method was established for...

The diagnosis of Bartter's syndrome was made in a 9-month-old boy investigated for poor weight and height gain. Initial treatment with oral potassium supplements and later spironolactone had little or no effect on his growth, although plasma potassium rose to normal after spironolactone. At 33 months indomethacin therapy was started with dramatic results. His symptoms went and his height and we...