Bilirubin induced brain damage is still a common cause of morbidity and mortality in Nigerian infants. No much success has been recorded in decades despite the fact that brain damage from bilirubin toxicity in the newborn is easily preventable with affordable and effective means. We report a case of a newborn with acute bilirubin encephalopathy. This case was considered of interest because the ...

Neonatal jaundice often occurs in newborns characterized by a yellow discoloration of the sclera and baby's skin due to high levels bilirubin blood. The occurrence needs done identified development hyperbilirubinemia which has potential become toxic that can cause kernicterus. Detection manual (visual) is still parents health workers, so results diagnosis obtained are less accurate. This study ...

Gilbert’s syndrome is a genetic disorder characterised by non-hemolytic unconjugated hyperbilirubinemia. It caused mutations in the UGT1A1 gene which codes for enzyme uridine diphosphate glucoronosyl transferase-1, conjugates bilirubin excretion. Affected individuals are usually asymptomatic apart from mild jaundice and investigations reveal isolated indirect This may be exacerbated face of env...

Red cell alloimmunisation in pregnancy may result haemolytic disease of the foetus and newborn (HDN). During pregnancy, there are possibilities foetal antigen being exposed to mother’s circulation, thereby leading production antibodies. The immunoglobulin G (IgG) antibodies from mother pass through maternal surface placenta, which is then sensitised obstructs formation red blood cells (RBCs). T...

Neonatal jaundice which is yellow coloration of the skin and sclera in newborns from the accumulation of unconjugated bilirubin occurs in most newborn infants and it is the most common condition that requires medical attention in newborns. Most jaundice is benign (physiological) and usually need no treatment as it resolves within two weeks. However, the diagnosis of physiological jaundice is re...

Severe unconjugated hyperbilirubinemia, seen mainly in neonates, may cause kernicterus and death. Conventional treatment for severe unconjugated hyperbilirubinemia consists of phototherapy and exchange transfusion. Phototherapy, however, has several known disadvantages while exchange transfusion is associated with a significant morbidity, and even mortality. These harmful effects indicate the n...

Care of the high-risk neonate usually refers to the low-birth-weight infant or the sick term newborn. Whereas hyperbilirubinemia is certainly a matter of concern in these infants, the decisions that must be made regarding jaundice in the high-risk neonate are, in general, less complex than those that must be made for the healthy full-term infant. For the term and near-term infant, shorter hospi...