PURPOSE The purpose of this study was to characterize aberrations in 2 populations of eyes, namely those with keratoconus (KC) and those having undergone penetrating keratoplasty (PK), using a large-dynamic range Shack-Hartmann wavefront sensor. DESIGN Prospective comparative case series. PARTICIPANTS Twenty-one people with ocular pathologic features (either KC or PK) were recruited for thi...

PURPOSE To illustrate the histopathology of keratoconic corneal epithelia and its micro-ribonucleic acid (miRNA) regulation. METHODS Corneal epithelia were collected from 27 patients with keratoconus and 26 normal patients after surgery or by impression cytology. The miRNA profile was determined using miRNA microarray. The biological roles of miRNA target genes were delineated by gene ontolog...

PURPOSE Intrastromal corneal-ring segments (ICRSs) are applied to improve highly distorted vision in keratoconic, myopic, and astigmatic patients. Selections of ICRS geometry and position are primarily based on empirical nomograms. We developed a finite-element model (FEM) predicting the corneal response to different ICRS geometries in normal and keratoconic corneas. METHODS A two-dimensional...

PURPOSE To compare the visual, refractive, and keratometric outcomes of single-segment conventional and severe keratoconus (SK) types of Intacs for correction of inferior keratoconus (KCN). METHODS A total number of 41 consecutive eyes of 23 patients with a diagnosis of inferior KCN underwent Intacs implantation. Eight eyes were excluded due to postoperative complications (4 eyes) and loss to...

PURPOSE A previous study has indicated suggestive association of the hepatocyte growth factor (HGF) gene with Keratoconus. We wished to assess this association in an independent Caucasian cohort as well as assess its association with corneal curvature. PARTICIPANTS Keratoconus patients were recruited from private and public clinics in Melbourne, Australia. Non-keratoconic individuals were ide...

PURPOSE We detected keratoconus cases with a significant potential for poor outcomes following intracorneal ring segment implantation (ICRS). We attempted to predict the potential of a case in terms of gain or loss of corrected distance visual acuity (CDVA). METHODS In this retrospective and prospective, consecutive, nonrandomized, multicentric study, 58 keratoconic eyes (aged 1756) were impl...

AIM To describe initial lens selection and our experience of Rose K lens fitting in keratoconus in Indian eyes. METHODS Retrospective study of patients who underwent the Rose K contact lens (CL) trial during a 6-month period from July 2007 to December 2007 in a tertiary eye care centre in South India. We obtained data on patient demographics, prefitting refraction and best spectacle-corrected...