BACKGROUND Comèl-Netherton syndrome is an inherited ichthyosis that is associated with highly impaired epidermal cornification and barrier function. Literature sparsely reports of the occurrence of early onset skin cancer in people with Netherton syndrome. To the best of our knowledge the suitability of the severely altered skin in patients with Netherton syndrome for techniques of facial plast...

Pityriasis rubra pilaris is a rare chronic inflammatory papulo-squamous skin disease, the pathogenesis of which still unclear. The pathological essence disease associated with violation keratinization against background hyperactivity keratinocytes subsequent inflammation, as well vitamin A dysmetabolism and weakening protein-binding fiction liver. Unfortunately, treatment complex inconsistent i...

In both the initial biopsy and the complete excision of the lesion, specimens were obtained for hematoxylin-eosin staining. Both specimens showed a well-defined, unencapsulated cystic tumor formed by several different-sized lobules composed of an external layer of basaloid cells and several layers of eosinophilic spindle cells with abrupt keratinization (Fig. 2). No atypia or mitotic figures we...

Porokeratosis is a disorder of epidermal keratinization characterized by the presence of annular hyperkeratotic plaques. Its etiopathogenesis is not yet fully understood, but a relationship with immunosuppression has been reported. Dermoscopic examination revealed a classic yellowish-white ring-like structure that resembled "volcanic crater contour" - the so-called cornoid lamella. We describe ...

An alkaline phosphatase that exhibited immunological specificity towards the mouse uterus was liberated in the serum during uterine carcinogenesis induced by dimethylbenzanthracene. A correlation was observed between the presence of neoplastic lesions and the appearance of this alkaline phosphatase in the serum. This specific protein, which was immunohistochemically localized in the endometrial...

Acne vulgaris is a chronic inflammatory skin disease of the pilosebaceous unit. Its pathogenesis multifactorial and involves overlap between four main processes: alteration keratinization, increased sebum production, colonization with Cutibacterium acnes, inflammation. The role oxidative stress (OS) has been intensively studied in conditions such as psoriasis, vitiligo, or atopic dermatitis. Ho...

In both the initial biopsy and the complete excision of the lesion, specimens were obtained for hematoxylin-eosin staining. Both specimens showed a well-defined, unencapsulated cystic tumor formed by several different-sized lobules composed of an external layer of basaloid cells and several layers of eosinophilic spindle cells with abrupt keratinization (Fig. 2). No atypia or mitotic figures we...

OBJECTIVE To observe the effects of low intensity laser therapy in inflammation, wound healing and epithelialization of island skin grafts. METHODS Twenty rats were subjected to this grafting technique and divided subsequently into two equal groups, one treated with laser and the other control. RESULTS there was less inflammation, faster healing, epithelialization and keratinization in the ...

ABSTRACT Dandruff is often seen in the primary care setting as well as in the dermatology field. In this article, we review the most commonly prescribed topical shampoos for treating dandruff and compare their efficacy in eradicating the symptoms of dryness and flaking of the scalp, along with providing relief of associated pruritus. Examples of such agents include keratolytics, regulators of k...

Porokeratosis, a keratinization and fibroblast cutaneous disorder, is a progressive disease with limited treatment options. We describe a case of linear porokeratosis that responded favorably to a series of 585 nm pulsed dye laser treatments. In addition to its vascular specificity, the pulsed dye laser presumably produces a direct effect on collagen, as well as an indirect effect on histamine ...