Mitochondrial mutations, an important cause of incurable human neuromuscular diseases, are mostly heteroplasmic: mutated mitochondrial DNA is present in cells simultaneously with wild-type genomes, the pathogenic threshold being generally >70% of mutant mtDNA. We studied whether heteroplasmy level could be decreased by specifically designed oligoribonucleotides, targeted into mitochondria by th...

We consider safety games on finite, edge-labeled graphs and present an algorithm based on automata learning to compute small strategies. Our idea is as follows: we incrementally learn regular sets of winning plays until a winning strategy can be derived. For this purpose we develop a modified version of Kearns and Vazirani’s learning algorithm. Since computing a minimal strategy in this setting...

From the Departments of Pediatrics (G.L.K., S.M.A.-R., S.W.A., D.L.B., J.S.L., R.E.K.), Pharmacology (G.L.K., D.L.B., J.S.L., R.E.K.), and Pharmacy Practice (S.M.A.-R.), University of Missouri at Kansas City; and the Divisions of Pediatric Pharmacology and Medical Toxicology (G.L.K., S.M.A.-R., S.W.A., D.L.B., J.S.L., R.E.K.), Emergency Medicine (S.W.A.), and Nephrology (D.L.B.), Children’s Mer...

H. K. GREEN, A. CHARLETT, J. MORAN-GILAD, D. FLEMING, H. DURNALL, D. RH. THOMAS, S. COTTRELL, B. SMYTH, C. KEARNS, A. J. REYNOLDS, G. E. SMITH, A. J. ELLIOT, J. ELLIS, M. ZAMBON, J. M. WATSON, J. MCMENAMIN AND R. G. PEBODY* Respiratory Diseases Department, Centre for Infectious Disease Surveillance and Control, Public Health England, London, UK Royal College of General Practitioners, Birmingham...

We study the computational complexity of computing Nash equilibria in generalized interdependent-security (IDS) games. Like traditional IDS games, originally introduced by economists and risk-assessment experts Heal and Kunreuther about a decade ago, generalized IDS games model agents’ voluntary investment decisions when facing potential direct risk and transfer-risk exposure from other agents....

Kearns and Star have previously recommended that we measure the degree to which a reason supports conclusion, either about how act or what believe, as conditional probability of conclusion given reason. I show properly formulate this recommendation allow for dependencies among considerations being aggregated. This formulation allows us account considerations, do not themselves favour specific c...

The innovation of the android-based audio visual integrated system (AVIS) online limited area application by Cimahi police resort, which is relatively new, still requires a lot improvement and refinement. This study aimed to determine use Android-based AVIS how optimizing application. research was conducted with qualitative approach, using descriptive analysis methods, as well data collection t...