The rate of treatment failure in cases of rectal gonorrhoea has been the source of considerable concern in recent years and it was therefore decided to investigate the value of kanamycin for this condition. As pointed out by Jefferiss (1966), the true incidence of gonorrhoea in passive homosexuals is undoubtedly greater than the figures of proven infections would suggest, as there are many case...

Inhalation of nebulized antibiotics is associated with respiratory distress in some patients but the effect on the airways has not been studied. Ventilatory function was studied immediately before and 20 minutes after inhalation in patients having chronic lung disease, who were being treated with inhaled antibiotics. Kanamycin was associated with minor changes in ventilatory function but polymy...

Abstract The influence of TDZ on adventitious shoot regeneration from leaves the pear cultivars Conference and Abate Fétel, rootstock Farold ® 87 was investigated. Our main aim to set up efficient in vitro protocols for all these genotypes by using expanding elongated cultures as starting plant material. best results terms percentage were achieved half-strength Murashige Skoog basal medium supp...

Protocols for the production and transformation of grapevine embryogenic cultures are described. Embryogenic cultures are initiated from leaves or stamens and pistils and transformed with Agrobacterium containing an enhanced green fluorescent protein/neomycin phosphotransferase II (egfp/nptII) fusion gene. Cultures are transferred to induction medium in the dark for callus formation and prolife...

The pharmacokinetics of gentamicin, kanamycin, and creatinine were studied in patients undergoing hemodialysis. After intravenous injection of single doses of the drugs, 50 to 60% of the doses of both antibiotics were cleared from the body during a 6-h period; this occurred almost entirely by the hemodialysis process. No correlation was found between the dialysance of the aminoglycosides and cr...

A strain of Proteus vulgaris isolated from the urinary tract of a patient with postoperative pyelonephritis and resistant to sulfonamide, streptomycin, tetracycline, and kanamycin (KM) was found to transfer only KM resistance by cell-to-cell conjugation. The genetic determinant controlling the transferable KM resistance was considered to be an R factor and was designated R (KM). Successive tran...

We demonstrate new method for the synthesis of gold and silver nanoparticles from pineapple extract. Furthermore, we have studied interactions between nanoparticles (gold and silver) with aminoglycosides such as Kanamycin A, Neomycin. Both nanoparticles were prepared by reducing AuCl4 and AgNO3 using pineapple extract, kanamycin A and neomycin as both reducing and stabilizing agents respectivel...

Plasmid pSUP5011 contains a pMBl origin of replication, an origin of transfer (oriT), and genes encoding resistance to the antibiotics ampicillin, chloramphenicol and kanamycin. pSUP5011 was conjugally mobilized from Escherichia coli into the non-heterocystous, filamentous, nitrogen-fixing cyanobacterium Plectonema boryanum UTEX 594 in the presence of a helper plasmid, RP4. Transconjugant cyano...

On the basis of parallel in vitro studies with antibiotic G-418, gentamicin, neomycin, and kanamycin, antibiotic G-418 was found to be less potent than gentamicin but more active than either kanamycin or neomycin against most strains, with the exception of Pseudomonas, for which neomycin was more active than antibiotic G-418, and enterococci, for which antibiotic G-418 was more active than the ...

The synthesis and antiviral activity of 1-N-palmitoyl- or 1-N-(3-hydroxytetradecanoyl)-kanamycin A derivatives (7,8) having various type of acyl substituents at the N-3" position were investigated. The structure-activity relationships between the antiviral activity and the substituent at the N-3" position is described. In this series, 3"-N-acetyl-1-N-palmitoyl-kanamycin A (7c) showed the excell...