نتایج جستجو برای: k562

تعداد نتایج: 4081  

Journal: :The Journal of antibiotics 1988
J Magae C Watanabe H Osada X C Cheng K Isono

A novel antibiotic tautomycin induced many blebs on the surface of K562 human chronic myeloid leukemia cells, similar to the morphological changes induced by phorbol esters. However, tautomycin did not induce nitroblue tetrazolium reducing activity, when HL60 human promyelocytic leukemia cells were caused to differentiate by quinomycin into mature granulocytes. It did not induce spread of HL60 ...

Journal: :Blood 1987
Y Yamada T Amagasaki D W Jacobsen R Green

Monocytes and macrophages have receptors for the iron-binding protein lactoferrin. Lactoferrin acts as a potent inhibitor of granulocyte-macrophage colony stimulating factor production when it binds to these cells. Using a rosette assay and immunofluorescence, we have shown that cultured leukemia cells, including the human erythroid leukemia cell line K562, also have lactoferrin binding sites. ...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2013
Zafer Akan Ayse Inhan Garip

Quercetin is one of the most abundant dietary flavonoids widely present in many fruits and vegetables. Previous in vitro studies has shown that quercetin acts as an antioxidant and anti-inflammatory agent and it has potent anticarcinogenic properties as an apoptosis inducer. In this study we examined apoptotic effects of quercetin on the K562 erythroleukemia cell line. K562 cells were induced t...

Journal: :Advanced pharmaceutical bulletin 2014
Negin Seyed-Gogani Marveh Rahmati Nosratollah Zarghami Iraj Asvadi-Kermani Mohammad Ali Hoseinpour-Feyzi Mohammad Amin Moosavi

PURPOSE Despite significant improvements in treatment of chronic myelogenous leukemia (CML), the emergence of leukemic stem cell (LSC) concept questioned efficacy of current therapeutical protocols. Remaining issue on CML includes finding and targeting of the key genes responsible for self-renewal and proliferation of LSCs. Nucleostemin (NS) is a new protein localized in the nucleolus of most s...

2012
Ming Liu Xiangzhong Zhao Jin Zhao Lin Xiao Haizhou Liu Cuicui Wang Linyou Cheng Ning Wu Xiukun Lin

Mere15 is a novel polypeptide from Meretrix meretrix Linnaeus with cytotoxicity in solid cancer cells. In this study, we investigated its activity on human K562 chronic myelogenous leukemia cells. Mere15 inhibited the growth of K562 cells with IC₅₀ values of 38.2 μg/mL. Mere15 also caused concentration dependent induction of apoptosis, with overproduction of reactive oxygen species and loss of ...

2001
Roland Beckmann Jonathan S. Smythe David J. Anstee Michael J. A. Tanner

K562 cells were stably transfected with cDNAs encoding the band 3 found in Southeast Asian ovalocytosis (B3SAO, deletion of residues 400-408), band 3 with a transport-inactivating E681Q point mutation (B3EQ), or normal band 3 (B3). Flow cytometric analysis and quantitative immunoblotting revealed that B3SAO expressed alone was translocated to the plasma membrane, at levels similar to B3 or B3EQ...

Journal: :Biochemical and biophysical research communications 2008
Ying Lu Tianxiang Pang Jianxiang Wang Dongsheng Xiong Li Ma Bin Li Qinghua Li Shigeo Wakabayashi

We have investigated the involvement of intracellular pH (pH(i)) in the regulation of P-glycoprotein (P-gp) in K562/DOX cells. The selective Na(+)/H(+) exchanger1 (NHE1) inhibitor cariporide and the "high K(+)" buffer were used to induce the sustained intracellular acidification of the K562/DOX cells that exhibited more alkaline pH(i) than the K562 cells. The acidification resulted in the decre...

Journal: :Journal of Asian natural products research 2009
Yan-Li Jia Jun Li Zheng-Hong Qin Zhong-Qin Liang

Curcumin (1), a natural polyphenolic compound, has shown strong antioxidant and anticancer activities. Several molecular mechanisms have been attributed to its inhibitory effects on a wide range of tumor cells. In this study, the response of the chronic myeloid leukemia cell line K562 cells to 1 is investigated. Curcumin inhibited the viability of K562 cells in a dose- and time-dependent manner...

ژورنال: :مجله دانشگاه علوم پزشکی مازندران 0
فروغ عالمی سرج forogh alemi serej علوم پزشکی مازندران مجید مهدوی majid mahdavi علوم پزشکی مازندران پیمان زارع peyman zare علوم پزشکی مازندران محمد علی حسین پورفیضی mammad ali hosseinpourfeizi علوم پزشکی مازندران سعید بلالایی saeed balalaei علوم پزشکی مازندرانعلوم پزشکی مازندرن

سابقه و هدف: لوسمی میلوئید مزمن (cml) از شناخته شده ترین اشکال لوسمی می باشد. امروزه تلاش برای یافتن ترکیبات سنتزی جدید یکی از استراتژی های پایه جهت یافت داروهای جدید برای درمان cml است. در این مطالعه اثرات مهار رشدی و آپوپتوزی 4 ترکیب آمینوپیریمیدونی بر روی رده سلولی لوسمی k562 مورد بررسی قرار گرفته است. مواد و روش ها: در این مطالعه از رده سلولی سرطانی k562 که مدل آزمایشگاهی لوسمی میلوئید مزمن...

ژورنال: :مجله دانشگاه علوم پزشکی کرمانشاه 0
zohreh faezizadeh amir gharib masoud godarzi

زمینه: آنزیم تلومراز در اغلب سلول های سرطانی فعالیت بالایی دارد، بنابراین مهار فعالیت آن می تواند به عنوان راهکار جدید و امیدبخش برای درمان سرطان مطرح گردد. برخی از ترکیبات ضدسرطانی مشتق شده از گیاهان از طریق مهار تلومراز و القاء آپوپتوز عمل می نمایند. گزارش شده بتاآیونن به عنوان یک کاروتنوئید استخراج شده از گیاهان خانواده roseaceae دارای خواص ضدسرطانی است. هدف از مطالعه حاضر بررسی اثر بتاآیونن...

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