نتایج جستجو برای: jurkat cell line
تعداد نتایج: 1970061 فیلتر نتایج به سال:
Anthrax lethal toxin (LT) is a critical virulence factor that cleaves and inactivates MAPK kinases (MAPKKs) in host cells and has been proposed as a therapeutic target in the treatment of human anthrax infections. Despite the potential use of anti-toxin agents in humans, the standard activity assays for anthrax LT are currently based on cytotoxic actions of anthrax LT that are cell-, strain-, a...
The human tetraspan molecule CD81 is a coreceptor in B and T cell activation and a candidate receptor for hepatitis C virus infection. We examined the surface expression of CD81 on B and T lymphocytes by quantitative flow cytometry. Upon cellular activation, CD81 surface levels were rapidly reduced. This reduction occurred as early as 1 h after activation and was linked to the release of CD81-p...
Podophyllotoxins represent an important and unique position among natural products. They serve as the starting material for the semi-synthetic anticancer drugs etopside and teniposide, so considerable attention has focused on the availability of these aryltetralin lignans. Linum is one of the genera, with some reports on the presence of podophyllotoxin and related compounds, such as L. album, L...
Cadmium (Cd) is a widespread environmental contaminant. Cd affects the cellular homeostasis and generates damage via complex mechanisms involving interactions with other metals, induction of oxidative stress and apoptotic or necrotic cell death, depending on the cell type and the concentration. The goal of the present study was to investigate the effect of exposure to CdCl(2) on the intracellul...
Podophyllotoxins represent an important and unique position among natural products. They serve as the starting material for the semi-synthetic anticancer drugs etopside and teniposide, so considerable attention has focused on the availability of these aryltetralin lignans. Linum is one of the genera, with some reports on the presence of podophyllotoxin and related compounds, such as L. album, L...
BACKGROUND Despite the high cure rate of T cell acute lymphoblastic leukemia (T-ALL), drug resistance to chemotherapy remains a significant clinical problem. Bone marrow mesenchymal stem cells (MSCs) protect leukemic cells from chemotherapy, but the underlying mechanisms are poorly understood. In this study, we aimed to uncover the mechanism of MSC-induced chemoresistance in T-ALL cells, thus p...
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