BACKGROUND There is an urgent need to improve lung cancer outcome by identifying and validating markers of risk. We previously reported that the cytokinesis-blocked micronucleus assay (CBMN) is a strong predictor of lung cancer risk. Here, we validate our findings in an independent external lung cancer population and test discriminatory power improvement of the Spitz risk prediction model upon ...

A key step in development is the establishment of cell type diversity across a cellular field. Segmental patterning within the Drosophila embryonic epidermis is one paradigm for this process. At each parasegment boundary, cells expressing the Wnt family member Wingless confront cells expressing the homeoprotein Engrailed. The Engrailed-expressing cells normally differentiate as one of two alter...

09.30 Francois Spitz Charting the genome regulatory architecture with transposons 14.00 Emmanouil Dermitzakis Regulatory genomics in human populations 09.30 Ivan Ovcharenko Computational identification and sequence analysis of enhancers 14.00 Gioacchino Natoli Deciphering cis-regulatory control of inflammatory cells 10.00 Discussion 14.30 Discussion 10.00 Discussion 14.30 Discussion 10.30 Coffe...

Spitz et al (2003[this issue of Cell]) describe the properties of a novel cis-regulatory DNA element, the global control region (GCR), which regulates gene expression over distances of several hundred kilobases at the mouse HoxD complex. The GCR provides an explanation for the colinear genetic linkage and expression of individual Hox genes within developing limbs.

It has been found that children with hydrocephalus, whose Spitz-Holter valves are colonized with Staph. albus, have an antibody to this organism in their serum. Children without colonized shunts have little or no such antibody. A test for this antibody is described, and its use in such cases is discussed.

Doris G. Bartuska, M.D., F.A.C.E. George W. Bray, M.D., M.A.C.E. C. Wayne Callaway, M.D., F.A.C.E. Eugene T. Davidson, M.D., M.A.C.E. Stanley Feld, M.D., M.A.C.E. Robert T. Ferraro, M.D. Stephen F. Hodgson, M.D., F.A.C.E. Paul S. Jellinger, M.D., F.A.C.E. Frank P. Kennedy, M.D. Ann M. Lawrence, M.D., Ph.D., M.A.C.E. Pasquale J. Palumbo, M.D., F.A.C.E. John A. Seibel, M.D., F.A.C.E. Adam F. Spit...

Authors present the evolution of psychoanalytical views of how a child perceives and contruct the world. They begin with Freud's thought and go through works of Klein, Spitz, Mahler, Bowlby, ending with modern thought of Stern. Developments in understanding of the infant by observations taken through the last thirty years are outlined and implications for psychoanalytical theory and treatment o...