Objective. To investigate the endocrine and/or clinical characteristics of women with low anti-Müllerian hormone (AMH) that could improve the accuracy of IVF outcome prediction based on the female age alone prior to the first GnRH antagonist IVF cycle. Methods. Medical records of 129 patients with low AMH level (<6.5 pmol/L) who underwent their first GnRH antagonist ovarian stimulation protocol...

In an attempt to examine whether body mass index (BMI) may influence IVF outcome in patients undergoing COH with either GnRH-agonist (agonist group) or GnRH-antagonist (antagonist group), we studied 799 IVF cycles: 481 in the agonist group and 318 in the antagonist group. In patients with BMI >25 kg/m(2), COH with either GnRH-agonist or GnRH-antagonist achieved a comparable outcome; whereas in ...

BACKGROUND This study was designed to evaluate the incidence of uterine pathologies in infertile women with a history of two implantation failures after in vitro fertilization (IVF) and estimate the effect of hysteroscopic correction on achieving a pregnancy in these patients. MATERIALS AND METHODS The retrospective study population included 238 infertile women attended the outpatient inferti...

STUDY QUESTION Does ovarian hyperstimulation, the in vitro procedures required for in vitro fertilization (IVF)/ intracytoplasmic sperm injection or the combination of both, affect the neurological outcome of 4-year-old singletons? SUMMARY ANSWER Ovarian hyperstimulation, the in vitro procedure and the combination of both, were not associated with the worse neurological outcome in 4-year-old ...

BACKGROUND Idiopathic ventricular fibrillation (IVF) is a rare cause of sudden cardiac arrest. Limited data are available on the long-term outcome of IVF patients. METHODS AND RESULTS In this retrospective cohort study, 107 consecutive patients with an initial diagnosis of IVF were analyzed (age at index event 40.4 years, 60% male). Missing diagnostic data were acquired during follow-up, incl...

BACKGROUND Anti-nuclear antibodies (ANA) are suspected of having relevance to adverse reproductive events. METHODS This study aims to investigate the potential effect of ANA on IVF/ICSI outcome and the therapeutic role of prednisone plus low-dose aspirin (P + A) adjuvant treatment in ANA + patients. The first IVF/ICSI cycles without P + A of sixty-six ANA + women were enrolled as the ANA + gr...

Background A major hurdle to improved in vitro fertilization (IVF) success rate is defective endometrial receptivity and implantation. Various techniques have been advocated to increase implantation while reducing side effects. Currently, embryo transfer (ET) is performed blindly without direct visualization. As such, we sought to develop a technique utilizing a flexible minihysteroscope with a...

ObjectiveTo identify predictor microRNAs (miRNAs) from patients with repeated implantation failure (RIF).DesignSystemic analysis of miRNA profiles the endometrium undergoing in vitro fertilization (IVF).SettingUniversity research institute, private IVF center, and molecular testing laboratory.Patient(s)Twenty five infertile discovery cohort 11 validation cohort.Interventions(s)None.Main Outcome...

Thanks to assisted reproduction technology (ART) most couples with infertility can be helped today. Since the beginning of ART, however, two major problems have existed. In the first years of IVF more than one embryo was transferred in order to reach acceptable pregnancy rates, but this entails a risk of multiple pregnancy with all its morbidity and mortality due to premature birth. Also, studi...

BACKGROUND Obesity is a common disorder with a negative impact on IVF treatment outcome. It is not clear whether morbidly obese women (BMI >= 35 kg/m2) respond to treatment differently as compared to obese women (BMI = 30-34.9 kg/m2) in IVF. Our aim was to compare the outcome of IVF or ICSI treatments in obese patients to that in morbidly obese patients. METHODS This retrospective cohort stud...