Activating mutations in FLT3 (Fms-like tyrosine kinase 3) by internal tandem duplication (ITD) mutations are found in approximately 30% of patients with acute myeloid leukemia (AML) and are associated with poor outcome in this patient population. Numerous FLT3 inhibitors have been tested for the treatment of AML, but these inhibitors have shown variable responses that were attributed to heterog...

Binaural recordings of noise in rooms were used to determine the relationship between binaural coherence and the effectiveness of the interaural time difference (ITD) as a cue for human sound localization. Experiments showed a strong, monotonic relationship between the coherence and a listener's ability to discriminate values of ITD. The relationship was found to be independent of other, widely...

In this study we searched the obtainable accuracy of forest inventory based on the individual tree detection (ITD) by using fusion of automatic ITD (ITDauto) and visual interpretation of laser point clouds. Current ITD algorithms, mostly based on segmentation of canopy height models (CHMs), are not able to utilize the whole information included in three-dimensional point clouds. We hypothesized...

Localization of sound sources relies on 2 main binaural cues: interaural time differences (ITD) and interaural level differences. ITD computing is first carried out in tonotopically organized areas of the brainstem nucleus laminaris (NL) in birds and the medial superior olive (MSO) in mammals. The specific way in which ITD are derived was long assumed to conform to a delay line model in which a...

Activatingmutations of the class III receptor tyrosinekinase FLT3are themost frequentmolecular aberration in acutemyeloid leukemia (AML).Mutant FLT3 accelerates proliferation, suppresses apoptosis, and correlates with poor prognosis. Therefore, it is a promising therapeutic target. Here, we show that RNA interference against FLT3with an internal tandemduplication (FLT3-ITD)potentiates the effic...

Simultaneity judgments were used to measure temporal binding windows (TBW) for brief binaural events (changes in interaural time and/or level differences [ITD and ILD]) and test the hypothesis that ITD and ILD contribute to perception via separate sensory dimensions subject to binding via slow (100+ ms)-presumably cortical-mechanisms as in multisensory TBW. Stimuli were continuous low-frequency...

• Structural aspects of the FLT3 receptor in signalling. Clonal evolution mutants. Recurrent mutations and its regulation signalling cascade drug therapy. Acute myelogenous leukaemia (AML) is an aggressive blood cancer characterized by rapid proliferation immature myeloid blast cells, resulting a high mortality rate. The 5-year overall survival rate for AML patients approximately 25%. Circa 35%...

Patients with acute myeloid leukemia (AML) harboring internal tandem duplication mutations of the FLT3 receptor (FLT3/ITD mutations) have a poor prognosis compared to patients lacking such mutations. Incorporation of FLT3 inhibitors into existing chemotherapeutic regimens has the potential to improve clinical outcomes in this high-risk group of patients. CEP-701, an indolocarbazole-derived sele...

A multiplicative combination of tuning to interaural time difference (ITD) and interaural level difference (ILD) contributes to the generation of spatially selective auditory neurons in the owl's midbrain. Previous analyses of multiplicative responses in the owl have not taken into consideration the frequency-dependence of ITD and ILD cues that occur under natural listening conditions. Here, we...