PURPOSE To evaluate the effectiveness of alcaftadine 0.05%, 0.1%, and 0.25% ophthalmic solutions in treating the signs and symptoms of allergic conjunctivitis when compared with olopatadine hydrochloride 0.1% and placebo using the conjunctival allergen challenge (CAC) model. METHODS One hundred and seventy subjects were randomized and 164 subjects completed all visits. CAC was performed to de...

Manipulation of the optic nerve can lead to irreversible vision changes. We present a patient with a past medical history of skin allergy and allergic conjunctivitis (AC) who presented with insidious unexplained unilateral vision loss. Physical exam revealed significant blepharospasm, mild lid edema, bulbar conjunctival hyperemia, afferent pupillary defect, and slight papillary hypertrophy. Sli...

BACKGROUND This study was conducted to investigate the efficacy and safety of 0.025% levocabastine hydrochloride in Japanese subjects with seasonal allergic conjunctivitis and its duration of action using the conjunctival allergen challenge (CAC) test. METHODS Twenty-four asymptomatic subjects were randomized to instill 0.025% levocabastine ophthalmic suspension in one eye and vehicle in the ...

BACKGROUND & AIMS The efficacy of currently available therapeutic agents for cholestatic pruritus is often disappointing. The aim of this study was to assess the antipruritic effect of naltrexone, an oral opiate receptor antagonist. METHODS Sixteen patients with pruritus of chronic cholestasis were randomized to receive naltrexone (4-week course of 50 mg naltrexone daily) or placebo. Pruritus...

OBJECTIVE To compare outcome of patients with burns covering less than 15% of total body surface area(TBSA) undergoing early excision and grafting or delayed skin grafting. METHOD This was a non-randomized clinical trial including 54 patients with less than 15% TBSA burn referring to Ghotboddin Hospital of Shiraz. They were assigned to two study groups, each group including 27 patients: the e...

background & aims: prevalence of uremic itch is 30% in patients on dialysis, and routine treatments are often ineffective.   materials & methods: we selected 40 hd patients and prescribed 100 mg gabapentin after each hd session for 20, and prescribe placebo for the other 20 patients. initial dose of gabapentin was 100mg after every thrice-weekly hd and altered the administered dose in the base ...

BACKGROUND/AIMS Dry, itchy and inflamed scalp conditions are common and often associated with diseases such as atopic dermatitis or psoriasis. To improve these symptoms, we investigated the efficacy of a new tonic containing the active ingredients urea, lactate, polidocanol, and Glycyrrhiza inflata root extract, containing licochalcone A. STUDY DESIGN/METHODS 30 subjects with dry and itchy sc...

INTRODUCTION Pruritus is one of the most common cutaneous complications in hemodialysis patients. There is no consensus on etiologic and pathologic factors. This study is aimed to evaluate the correlation between serum intact parathyroid hormone (PTH) level and the severity of pruritus in hemodialysis patients. MATERIALS AND METHODS In a cross-sectional study, all of the patients referred to ...

© 2009 Th e Serbian Association of Dermatovenereologists slightly elevated erythema, small erosions and slight oozing. At the beginning, the condition was not associated with pain or itching. Th e patient visited a private dermatologist. Th e submitted documentation showed that the patient had a sharply demarcated erythematous plaque of 30 x 30 mm in diameter; local therapy included betamethaso...