Abstract Background Sarcoptic mange causes significant animal welfare and occasional conservation concerns for bare-nosed wombats ( Vombatus ursinus ) throughout their range. To date, in situ chemotherapeutic interventions have involved macrocytic lactones, but short duration of action need frequent re-administration has limited treatment success. Fluralaner (Bravecto®; MSD Animal Health), a no...

A variety of new pyrazolines, isoxazolines, and amide derivatives were designed, synthesized, tested in vitro for their cytotoxic potential against the breast cancer cell line MCF-7. Nabumetone is a prodrug that used as non-steroidal anti-inflammatory drug
 
 (NSAID). Before synthesis, Molecular docking program (GOLD suite v. 5.7.1) was to evaluate selectivity ER-α receptor, which dem...