Isoflavones comprise a group of phytoestrogenic polyphenols with antioxidant properties occurring especially in plants of the Leguminosae family, and are consumed by humans mostly in form of soy (Glycine max (L.) Merr.) and products. Soy rich isoflavone products have been promoted recently as foods or supplements with functional or nutraceutical characteristics, especially for the prevention of...

Isoflavones, phytoestrogens contained in soy foods, may play a role in breast cancer prevention. This randomized double-blinded trial with 34 premenopausal women investigated whether 100 mg of isoflavones per day versus placebo affects the ovulatory cycle during 1 year. Compliance with the study regimen was confirmed by the increase of urinary isoflavone excretion among the intervention group. ...

The extraction efficiency, recovery, quantification, and stability of isoflavones (daidzein, genistein puerarin) from the wastes /by-products kudzu roots soy molasses were evaluated by using natural deep eutectic solvents (NADESs) coupled with ultrasound-assisted extraction. NADES was compared conventional Soxhlet technique, extracted quantified HPLC-UV/Vis. Results showed extractability puerar...

Silken tofu which retains soluble solids present in the soymilk was investigated for differences in the microstructure, sugars and isoflavones content from regular silken. Soy slurry treated with Viscozyme L (2.5 mL/L) was incubated for 30 minutes at 55°C. Stachyose was the predominant oligosaccharide in treated tofu, 4.58 g/100 g and 3.30 g/100 g in control tofu, raffinose content was 1.21 and...

Abstract Isoflavones from soy beans are used in functional food products as a measure to alleviate hormonedependent physiological disorders such as postmenopausal symptoms, osteoporosis and cardiovascular problems. These natural phytohormones are well perceived and do not show the negative side effects found in conventional therapies with hormones such as estrogens. A number of studies show tha...

Several dietary phytochemicals exhibit anti-oxidative, anti-inflammatory and anti-osteoporotic activities relevant to prevention of chronic diseases, including lifestyle-related diseases. Soybean isoflavones are similar in structure to estrogen and have received considerable attention as potential alternatives to hormone replacement therapy. Daidzein, a major isoflavone found in soybean, is met...

Electrospray ionization combined with tandem mass spectrometry was applied to a study of some representative chlorinated and nitrated isoflavones-potential metabolites of isoflavones in inflammatory cells. Upon collision-induced dissociation of deprotonated [M - H](-) ions of these compounds, a number of structurally characteristic product ions were produced. The product ion analysis of 3'- and...

INTRODUCTION Reduction of ovarian estrogen secretion at menopause increases net bone resorption and leads to bone loss. Isoflavones have been reported to protect bone from estrogen deficiency, but their modest effects on bone resorption have been difficult to measure with traditional analytical methods. METHODS In this randomized-order, crossover, blinded trial in 11 healthy postmenopausal wo...

Soy isoflavones are phytoestrogens with potential hormonal activity due to their similar chemical structure to 17-β-estradiol. The increasing availability of soy isoflavones throughout the food supply and through use of supplements has prompted extensive research on biological benefits to humans in chronic disease prevention and health maintenance. While much of this research has focused on adu...

Glycitein (4',7-dihydroxy-6-methoxyisoflavone) accounts for 5-10% of the total isoflavones in soy food products. The biological activity of this compound has not been reported to date, although numerous studies have been performed with the other soy isoflavones, daidzein and genistein. Glycitein was isolated from soy germ to 99% purity. Weaning female B6D2F1 mice were dosed with glycitein (3 mg...