Sympathetic nerve activity increases in the heart during cardiac failure. Here, we hypothesized that 1 integrins play a protective role in chronic -adrenergic receptor–stimulated cardiac myocyte apoptosis and heart failure. L-isoproterenol (iso; 400 g/kg per hour) was infused in a group of wild-type (WT) and 1 integrin heterozygous knockout (hKO) mice. Left ventricular structural and functional...

By means of EPR spectroscopy the behaviour of the vanadocene dichloride (I), Cp(2)VCl(2) (Cp=eta(5)-C(5)H(5)), in various deoxygenated and non-deoxygenated physiological media and therapeutic solution as well as in blood plasma and stabilized human blood was studied. On the basis of measured values of isotropic spectroscopic splitting factor g(iso) and isotropic hyperfine coupling constant A(is...

2',3'-iso-Benzoabscisic acid (iso-PhABA), an excellent selective abscisic acid (ABA) analog, was developed in our previous work. In order to find its more structure-activity information, some structural modifications were completed in this paper, including the substitution of phenyl ring and replacing the ring with heterocycles. Thus, 16 novel analogs of iso-PhABA were synthesized and screened ...

Problem statement: The International Organization for Standardization (ISO) published a set of international standards related to the software engineering, such as ISO 12207 and ISO 9126. However, there is a set of cross-references between these two standards. Approach: The ISO 9126 on software product quality and ISO 12207 on software life cycle processes had been analysed to investigate the r...

Background: Hospital standards are one of the valuest concepture items in an organization and hospital management. The research purpose was determination of luchs of hospital evaluation current way throght the comparission with ISO quality management standards and suggestion of a model to hospital standard development based on aquired findings. Materials & Methods: This research is a descripti...

Problem statement: The International Organization for Standardization (ISO) published a set of international standards related to the software engineering, such as ISO 12207 and ISO 9126. However, there is a set of cross-references between the two standards. Approach: The ISO 9126 on software product quality and ISO 12207 on software life cycle processes had been analyzed to invistigate the rel...

BACKGROUND Urinary 8-iso-PGF2α, a marker of oxidative stress, is influenced by the activation of NOX2. It is unclear if platelets 8-iso-PGF2α contribute to urinary 8-iso-PGF2α. METHODS AND RESULTS In a cross-sectional study, platelet, urinary, and serum 8-iso-PGF2α were determined in subjects with downregulation (X-linked chronic granulomatous disease [X-CGD], n=25) and upregulation (type II ...

BACKGROUND PSEN2 mutations are rare variants, and fewer than 30 different PSEN2 mutations have been found. So far, it has not been reported in Asia. CASE PRESENTATION PSEN2 mutation at codon 214 for predicting a valine to leucine substitution was found in a 70-year-old woman, who showed a dementia of the Alzheimer type. We did not find the mutation in 614 control chromosomes. We also predicte...