reaction of aryl methyl ketone with isatin in the presence of a base afforded 2- arylquinoline-4-carboxylic acid (3). reaction of diazomethane with compound 3 yielded the ester 4. compound 5 was prepared from the reaction of n, n'-dialkylethyl (or propyl) arnine with 4. addition of hydrazine hydrate to compound 4a gave 2- (2- pyridyl) quinoline-4-carboxylic acid hydrazide (6). reaction of ...

We examined the effect of ondansetron, an antagonist of type 3 serotonin receptors, on the whole cell response of freshly isolated hippocampal CA1 pyramidal neurons of neonatal and "mature" rats to glycine using the gramicidin perforated patch technique. Ondansetron depressed the current induced by subsaturating concentrations of glycine (IGly) in a concentration-dependent manner. The ondansetr...

THE TITLE COMPOUND [SYSTEMATIC NAME: 5-(trifluoro-meth-oxy)-1H-indole-2,3-dione], C9H4F3NO3, crystallized with two mol-ecules in the asymmetric unit. Inter-molecular N-H⋯O hydrogen bonds link the mol-ecules to form layers parallel to the ab plane. In addition, π-π stacking inter-actions are observed with a centroid-centroid distance of 3.721 (1) Å. The near planarity of the two isatin ring syst...

Kinetics and a mechanistic investigation of the reaction between dimethyl acetylenedicarboxcylate (DMAD) and saccharin (N-H heterocyclic compound) has been spectrally studied in methanol environment in the presence of triphenylarsine (TPA) as a catalyst. Previously, in a similar reaction, triphenylphosphine (TTP) (instead of triphenylarsine) has been employed as a third reactant (not catalyst) ...

glycine, alanine and valine are taken as amino acids with an equal polar head and with thedifference in the length of hydrocarbon chains. the structural optimizations show the results of theisolated glycine, alanine and valine in the gases phase, at the hartree-fock level by means ofsto-3g,3-21g, 6-31g and 6-31+g basis sets. the calculations were performed for the ten (1-10)solvents using pcm m...

Isatin is a heterocyclic nitrogen compound that has attracted much interest in recent years due to its diverse biological and pharmacological activities. It can be used many medical applications, such as antidiabetic, antibiotic, anticancer agents. The isatin molecule also prepared from different substrates by various methods, the methods of Sandmeyer, Stolle, Gassman, Meanwell Hewawasam others...

We previously reported the potential of a novel small molecule (E)-methyl 3-(1-(4-methoxybenzyl)-2, 3-dioxoindolin-5-yl) acrylate (HKL 2-3-15) as an anticancer agent. This study was focused on the molecular mechanisms by which HKL 2-3-15 exerts its cytotoxic activity in human gastric cancer MGC-803 cells. We showed that HKL 2-3-15 induced G2/M phase arrest in a time-dependent and dose-dependent...

A series of novel 1[5"-(2"'-substituted phenyl)-4",5"'-dihydro isoxazole-3"-yl]-3-[(4 substituted phenyl)imino]1-3-dihydro-2H-indole-2-one were synthesized from different substituted chalconised indole-2,3-dione was prepared from the different chalconised Isatin. The structures of the compounds were elucidated by elemental and spectral (IR, (1)H NMR, and MS) analysis. The synthesized compounds ...