Increased yield of chromatid breaks, following in vitro G2-phase lymphocyte irradiation, can be a marker of individual radiosensitivity and cancer predisposing genes whose role is to respond to DNA damage. Mutations or polymorphisms of genes encoding DNA repair pathways may underlie the increased chromosomal radiosensitivity. However, genes that facilitate DNA damage recognition, using signal t...

We read with great interest the recently published article by Müller [1]. Th e author aimed to explain the importance of high-resolution manometry (HRM) on achalasia diagnosis and management. She explained conventional manometry (CM) and HRM criteria for diagnosis of achalasia. We thank Muller for this valuable study, but we think that there are some controversies needed to be clarifi ed. First...

Idiopathic recurrent pericarditis (IRP) and adult-onset Still's disease (AOSD) are polygenic autoinflammatory diseases, in the pathogenesis of which pro-inflammatory cytokines from interleukin-1 superfamily play a central role. Aim . To compare serum concentrations proinflammatory glycosylated ferritin (GF) patients with IRP AOSD during an exacerbation. Material methods The study included 15 AO...

In many contexts, logistics is used to enable competitive advantages and cost savings. For some companies, logistics itself is its core competency (i.e. logistics providers). In this context, vendor-managed inventory (VMI) systems are one of the most up-to-date strategies allowing companies to reach a superior performance. Under a VMI strategy, the replenishment and distribution making process ...

In case of locally advanced soft tissue sarcomas the extremities (STS), large size which does not allow resection with preservation limb, isolated regional perfusion (IRP) limb is considered as one effective treatment options. Aim. To evaluate long-term outcomes IRP melphalan under conditions hyperthermia for STS extremities. Materials and methods. We conducted a prospective cohort clinical stu...

Iron regulatory proteins (IRPs) regulate the expression of genes involved in iron metabolism by binding to RNA stem-loop structures known as iron responsive elements (IREs) in target mRNAs. IRP binding inhibits the translation of mRNAs that contain an IRE in the 5'untranslated region of the transcripts, and increases the stability of mRNAs that contain IREs in the 3'untranslated region of trans...

Background and study aims Peroral endoscopic myotomy (POEM) is an excellent endoscopic treatment for achalasia. Clinical and manometric parameters are used for evaluation and follow-up. However, clinical success does not guarantee high quality of life (QoL) scores, generating doubts about their direct relationship. We aimed to evaluate QoL scores before and after POEM at medium and long term, t...

Hormones and neurotransmitters are released when secretory granules or synaptic vesicles fuse with the cell membrane, a process denoted exocytosis. Modern imaging techniques, in particular total internal reflection fluorescence (TIRF) microscopy, allow the investigator to monitor secretory granules at the plasma membrane before and when they undergo exocytosis. However, rigorous statistical app...

Anthracyclines are effective antineoplastic agents. However, the interaction of these drugs with iron (Fe) is an important cause of myocardial toxicity, limiting their therapeutic use (J Lab Clin Med 122:245-251, 1993). To overcome this limitation, it is crucial to understand how anthracyclines interact with the Fe metabolism of myocardial and neoplastic cells. Iron-regulatory proteins (IRPs) p...

Thomas Corbett is an IRP affiliate and Assistant Professor, Division of University Outreach, Department of Governmental Affairs, University of Wisconsin-Madison. The author was a contributor to the 1986 study of the welfare magnet phenomenon commissioned by the Wisconsin Expenditure Commission that is discussed in this article. He has remained interested in the subsequent debate about the issue.