A 66-year-old male patient presented with a 4-month history of progressive muscle weakness. Twelve years prior to presentation he was evaluated for fatigue, weight loss, new-onset diabetes and elevated liver enzymes and was diagnosed with hereditary hemochromatosis, homozygous for the C282Y mutation in the HFE gene. His total iron at diagnosis was 137 mcg/dL; iron binding capacity, 149 mcg/dL; ...

This data article contains data related to the research article entitled, "Synchrotron X-ray microscopy reveals early calcium and iron interaction with crocidolite fibers in the lung of exposed mice" [1]. Asbestos fibers disrupt iron homeostasis in the human and mouse lung, leading to the deposition of iron (Fe) onto longer asbestos fibers which forms asbestos bodies (AB) [2]. Similar to Fe, ca...

The oral administration of iron to anaemic infants often fails to restore the haemoglobin level as rapidly as it would in an adult. The reason for this failure could be either failure of absorption or failure to utilize the iron which had been absorbed, or deposition of all the iron in the tissue stores without any being incorporated in the haemoglobin. It was therefore decided to study the abs...

| 1096 | haematologica | 2008; 93(7) In conclusion, in never or minimally transfused patients with thalassemia intermedia we found no evidence of cardiac iron overload, while there may be significant hepatic iron accumulation. However, since cardiac MRI has not been routinely used in TI, further studies and longer follow-up are needed to understand if and when detectable cardiac iron deposition...

We have studied the structure of monolayers of iron on a Cu(001) substrate. By means of molecular-dynamics simulations in combination with embedded-atom potentials for the description of the interactions between the atoms, we have investigated the growth of bcc domains in the iron film with decreasing temperature. It turns out that the bcc domains become larger with decreasing temperature, but ...

Diabetic nephropathy is one of the most important complications of diabetes mellitus (1). Recently much attention has been directed toward the use of silymarin in diabetic nephropathy (2). Silymarin possesses antioxidant and antiproteinuric effects in humans and in animal models (2,3). Silymarin seems to have two different effects in diabetic patients (2,3). Firstly control of blood sugar and s...

Idiopathic haemochromatosis is an inherited defect of iron metabolism characterised by excessive iron absorption and deposition in the tissues leading to damage in the liver and other organs.' The nature of the fundamental metabolic abnormality remains unknown, but the liver and the gut have both been proposed as the principal site of expression of the metabolic defect.' We recently had the opp...

DEAR EDITOR, The recently published an article by Nematbakhsh et al., entitled “Protective role of silymarin and deferoxamine against iron dextran‐induced renal iron deposition in male rats,” had some interesting point’s needs to explain more. They studied rats, which were allocated to six group and they received iron dextran for a period of 4 weeks every other day, but at the beginning of week...