Natural occurring iron oxides, such as Fe2O3, Fe3O4, and FeO, are abundant on Earth's surface feature many implications in our daily life since the Iron Age, final epoch of prehistory humanity. The physics oxides is at frontier physical research due to their complicated magnetic electronic properties. What makes it even more intriguing introduction pressure, which not only regulates crystal str...

Redox-inactive metal ions that function as Lewis acids play pivotal roles in modulating reactivities of oxygen-containing metal complexes in a variety of biological and biomimetic reactions, including dioxygen activation/formation and functionalization of organic substrates. Mononuclear nonheme iron(III)-peroxo species are invoked as active oxygen intermediates in the catalytic cycles of dioxyg...

From our experimental evidence that iron lirnitation greatly increases the extracellular concentration of strong copper-complexing agents in cultures of Anabaena flos-aquae and Anabaena cyhdrica, and that the iron-algal exudate complex is much more stable than the copper complex, we conclude that strong copper-complexing agents released by filamentous blue-green algae are siderophores. Further ...

With the challenge of optimizing iron delivery, new intravenous (iv) iron-carbohydrate complexes have been developed in the last few years. A good example of these new compounds is ferric carboxymaltose (FCM), which has recently been approved by the US Food and Drug Administration for the treatment of iron deficiency anemia in adult patients who are intolerant to oral iron or present an unsatis...

To acquire iron, Pseudomonas aeruginosa secretes the fluorescent siderophore pyoverdine (Pvd), which chelates iron and shuttles it into the cells via the specific outer membrane transporter FpvA. We studied the role of iron and other metals in the binding and transport of Pvd by FpvA and conclude that there is no significant affinity between FpvA and metal-free Pvd. We found that the fluorescen...

Iron is a prerequisite for in vitro growth of mycobacteria. Iron is an obligate cofactor for at least 40 different enzymes encoded in the Mycobacterium tuberculosis genome (8). It is required for the cytochromes involved in electron transport and other hemoproteins involved in oxygen metabolism, such as catalase-peroxidase KatG. Most of the intracellular iron in mycobacteria, however, is in the...

The Rieske iron-sulfur protein, one of the catalytic subunits of the cytochrome bc(1) complex, is involved in electron transfer at the level of the inner membrane of yeast mitochondria. The Rieske iron-sulfur protein is encoded by nuclear DNA and, after being synthesized in the cytosol, is imported into mitochondria with the help of a cleavable N-terminal presequence. The imported protein, besi...