Exercise provides clear beneficial effects for the prevention of numerous diseases. However, many of the molecular events responsible for the curative and protective role of exercise remain elusive. The recent discovery of FNDC5/irisin protein that is liberated by muscle tissue in response to exercise might be an important finding with regard to this unsolved mechanism. The most striking aspect...

Ursolic acid (UA), a type of pentacyclic triterpenoid carboxylic acid purified from natural plants, can promote skeletal muscle development. We measured the effect of resistance training (RT) with/without UA on skeletal muscle development and related factors in men. Sixteen healthy male participants (age, 29.37±5.14 years; body mass index=27.13±2.16 kg/m(2)) were randomly assigned to RT (n=7) o...

Background. Irisin is the result of the proteolysis of fibronectin type III domain-containing protein 5, the levels of which are determined by physical activity. Objective(s). This study aims to identify changes in FNDC5 gene expression and the heart muscle irisin levels in male rats following 8 weeks resistance and endurance training. Methods. Fifteen male rats (10-12 weeks old and 331.8&plu...

Myokines are peptides produced and secreted by the skeletal muscle, with autocrine, paracrine, and endocrine actions. Many of them are overexpressed during physical exercise and appear to contribute to the benefits of exercise to metabolic homeostasis. Irisin, resulting from the cleavage of the membrane protein FNDC5, was shown to induce adipocyte browning, with increased lipid oxidation and th...

Irisin is secreted by skeletal muscle during exercise and influences energy and metabolic homeostasis. This hormone is a cleaved and secreted fragment of fibronectin type III domain-containing 5 (FNDC5). Elucidation of the FNDC5 gene regulation mechanism is necessary to clarify the function of irisin as a potential therapeutic target in human metabolic diseases. Thus, we investigated the geneti...

Purpose: The aim of this study was to determine the levels irisin in heart, which is a vital organ, rats different ages and reveal whether Ferula elaeochytris (FE) has an effect on expression irisin. 
 Materials Methods: Our designed six groups, young (4 months), middle age (12 old (24 months) were given FE extract for 8 weeks their control groups. After that heart tissues taken measured b...

Effects of Alpha Ketoacid Combined with Hybrid Blood Purification Treatment on Nutritional Status, Renal Function and Expressions Serum Sclerostin, BMP-7, Irisin in Maintenance Hemodialysis Patients

Sports it is the best way to activate vital processes of different organs body hormones affect activity living organisms, so physiological changes occur across all systems as a result exercise. The study aims find out effect anaerobic exercise on concentrations irisin hormone and some hormonal variables in male sports practitioners, correlation between studied variables, with each other, mass c...