نتایج جستجو برای: irbesartan

تعداد نتایج: 849  

Journal: :Acta Crystallographica Section A Foundations of Crystallography 2011

Journal: :ACP journal club 2003
David L Bronson

D a t a s o u r c e s Studies were identified by searching MEDLINE, EMBASE/Excerpta Medica, the Cochrane Library, and International Pharmaceutical Abstracts using combinations of the terms candesartan, eprosartan, losartan, irbesartan, tasosartan, telmisartan, and valsartan and the terms headache, headache disorders, cluster headaches, tension headaches, and migraine; scanning reference lists o...

2011
Somisetti Narender Rao Sudhakar Babu

Development of a new improved and efficient process suitable for the large-scale production of Irbesartan has been described. The key steps are tetrazole formation from secondary amide for the preparation of the key intermediate 1-Benzyl-5-(4'-bromomethyl-biphenyl-2-yl)-1H-tetrazole (9), N-alkylation and debenzylation.

Journal: :The Journal of pharmacology and experimental therapeutics 2002
Marc P Maillard Christine Perregaux Catherine Centeno Joachim Stangier Wolfgang Wienen Hans-R Brunner Michel Burnier

In vitro studies have shown that telmisartan is an insurmountable angiotensin II subtype-1 (AT1) receptor antagonist. Herein, the molecular basis of this insurmountable antagonism has been investigated in vitro, and the effect of telmisartan has been compared in vivo with that of irbesartan and candesartan. Association and dissociation kinetics of telmisartan to AT1 receptors have been characte...

2016

Background. Patients with chronic kidney disease (CKD) are at risk of progression to end-stage renal disease and cardiovascular disease. Data from other populations and animal experiments suggest that neprilysin inhibition (which augments the natriuretic peptide system) may reduce these risks, but clinical trials among patients with CKD are required to test this hypothesis. Methods. UK Heart an...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2002
Peter Jacobsen Steen Andersen Kasper Rossing Birgitte V Hansen Hans-Henrik Parving

BACKGROUND Albuminuria and hypertension are predictors of poor renal and cardiovascular outcome in patients with diabetes. Approximately 30% of type 1 patients with diabetic nephropathy (DN) have albuminuria >1 g/day, and blood pressure >135 and/or >85 mmHg despite antihypertensive therapy with recommended doses of ACE inhibitor (ACEI) and diuretics. We tested the effect of dual blockade of the...

2016
Shau-Hsuan Li Hung-I Lu Alice Y.W. Chang Wan-Ting Huang Wei-Che Lin Ching-Chang Lee Wan-Yu Tien Ya-Chun Lan Hsin-Ting Tsai Chang-Han Chen

BACKGROUND The aim of this study was to investigate the effects of the angiotensin II/ angiotensin II type I receptor (AT1R) and angiotensin II type II receptor (AT2R) signaling pathway in esophageal squamous cell carcinoma (ESCC). METHODS Immunohistochemistry was performed to evaluate the expression levels of AT1R and AT2R in tissues from 152 surgically resected ESCC patients, and those expr...

2017

Background. Patients with chronic kidney disease (CKD) are at risk of progression to end-stage renal disease and cardiovascular disease. Data from other populations and animal experiments suggest that neprilysin inhibition (which augments the natriuretic peptide system) may reduce these risks, but clinical trials among patients with CKD are required to test this hypothesis. Methods. UK Heart an...

2017
PK Judge R Haynes WG Herrington BC Storey N Staplin A Bethel L Bowman N Brunskill P Cockwell R Dayanandan M Hill PA Kalra JJ McMurray M Taal DC Wheeler MJ Landray C Baigent A Baxter C Knott K Murphy K Wheatley J Emberson C Tomson P Roderick

Background Patients with chronic kidney disease (CKD) are at risk of progression to end-stage renal disease and cardiovascular disease. Data from other populations and animal experiments suggest that neprilysin inhibition (which augments the natriuretic peptide system) may reduce these risks, but clinical trials among patients with CKD are required to test this hypothesis. Methods UK Heart an...

2002
Antonio Coca Carlos Calvo Maria T Aguilera Rafael Marin

Background: When blood pressure (BP)-lowering efficacy is assessed by measurements taken in a clinic setting, angiotensin II-receptor antagonists show similar efftcacy to angiotensin-converting enzyme inhibitors and better tolerability. A search of MEDLINE to date, however, reveals no randomized, double-blind studies using ambulatory BP monitoring (ABPM) to compare the BP-lowering efficacy of i...

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