نتایج جستجو برای: ips emax
تعداد نتایج: 9054 فیلتر نتایج به سال:
In this paper, we study the strength of aggregation cuts for sign-pattern integer programs (IPs). Sign-pattern IPs are a generalization of packing IPs and are of the form {x ∈ Z+ | Ax ≤ b} where for a given column j, Aij is either non-negative for all i or non-positive for all i. Our first result is that the aggregation closure for such sign-pattern IPs can be 2-approximated by the original 1-r...
Nuclear reprogramming enables patient-specific derivation of induced pluripotent stem (iPS) cells from adult tissue. Yet, iPS generation from patients with type 2 diabetes (T2D) has not been demonstrated. Here, we report reproducible iPS derivation of epidermal keratinocytes (HK) from elderly T2D patients. Transduced with human OCT4, SOX2, KLF4 and c-MYC stemness factors under serum-free and fe...
Potential of human induced pluripotent stem cells derived from blood and other postnatal cell types.
Human induced pluripotent stem (iPS) cells have been generated from various cell types including blood cells, and offer certain advantages as a starting population for reprogramming postnatal somatic cells. Unlike adult stem cells, iPS cells can proliferate limitlessly in culture while retaining their potential to differentiate into any cell type, including hematopoietic lineages. Derivation of...
Topic. Additional interventions used to enhance the effectiveness of individual placement and support (IPS). Aim. To establish whether additional interventions improve the vocational outcomes of IPS alone for people with severe mental illness. Method. A rapid evidence assessment of the literature was conducted for studies where behavioural or psychological interventions have been used to supple...
This report describes our initial attempt to regenerate salivary glands using induced pluripotent stem (iPS) cells in vivo and in vitro. Glandular tissues that were similar to the adult submandibular glands (SMGs) and sublingual glands could be partially produced by the transplantation of iPS cells into mouse salivary glands. However, the tumorigenicity of iPS cells has not been resolved yet. I...
The bremsstrahlung flux-averaged cross sections for the photoneutron reactions $^{\text{93}}$Nb($\gamma $,xn;x=1-5)$^{\text{(93-x)m,g}}$Nb were measured in range of boundary energies $\gamma $-quanta $E_{\gamma \text{max}}$=33-93 MeV with a step $\Delta E_{\gamma \text{max}}\approx $ 2 MeV. isomeric ratios average cross-sections products $^{\text{93}}$Nb ($\gamma ,4n)$^{\text{89m,g}}$Nb and $,5...
در سال های اخیر ، دانشمندان سلولهای سوماتیک را به سلولهای شبه جنینی بنام سلولهای پرتوان القایی(ips) بازبرنامه ریزی کرده اند.با توجه به ادغام ژنومی وکتورهای لنتی یا رتروویروسی،و عوارض زیان آور متعاقب این ویروسها،تحقیقات فعلی بر بکارگیری ابزارهای بی خطر تر انتقال ژن معطوف شده است.آدنوویروسها ابزارهای مطمئنی برای انتقال وبیان ژن در سلولهای یوکاریوتی بشمار میروند.در این مطالعه، ما آدنووکتورهای حامل...
The cytosolic RNA helicases melanoma differentiation-associated gene 5 and retinoic acid-inducible gene-I and their adaptor IFN-β promoter stimulator (IPS-1) have been implicated in the recognition of viral RNA and the production of type I IFN. Complementing the endosomal TLR, melanoma differentiation-associated gene 5, and retinoic acid-inducible gene-I provides alternative mechanisms for vira...
Hepatitis B virus (HBV) is not eradicated by current antiviral therapies due to persistence of HBV covalently closed circular DNA (cccDNA) in host cells, and thus development of novel culture models for productive HBV infection is urgently needed, which will allow the study of HBV cccDNA eradication. To meet this need, we developed culture models of HBV infection using human induced pluripotent...
Most lysosomal storage diseases (LSDs) are life-threatening genetic diseases. The pathogenesis of these diseases is poorly understood. Induced pluripotent stem (iPS) cell technology offers new opportunities for both mechanistic studies and development of stem cell- based therapies. Here we report the generation of disease-specific iPS cells from mouse models of Fabry disease, globoid cell leuko...
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