Introduction: The prostaglandin E2 (PGE2), a cyclooxygenase (COX) product, play critical roles in the synaptic plasticity. Therefore, long term use of COX inhibitors may impair the synaptic plasticity. Considering the wide clinical administration of aspirin and its unknown effects on information processing in the brain, the effect of aspirin and sodium salicylate on the short term synaptic p...

Abstract* Introduction: Chronic morphine exposure can cause addiction and affect synaptic plasticity, but the underlying neural mechanisms of this phenomenon remain unknown. Herein we used electrophysiologic approaches in hippocampal CA1 area to examine the effect of chronic morphine administration on short-term plasticity. Methods: Experiments were carried out on hippocampal slices taken f...

Immune recognition of tumor targets by specific cytotoxic lymphocytes is essential for the effective rejection of tumors. A phase I clinical trial of ipilimumab (an antibody that blocks CTLA-4 function) in combination with bevacizumab (an antibody that inhibits angiogenesis) in patients with metastatic melanoma found favorable clinical outcomes were associated with increased tumor endothelial a...

Based on their own experience and knowledge of the literature, the authors review the pathobiological characteristics of peripheral T-cell lymphomas (PTCLs), focusing on the available prognostic indicators. The International Prognostic Index (IPI), which is based on age, performance status, lactate dehydrogenase [LDH], stage, and extranodal involvement, appears to be efficient as a prognostic i...

The pathogenesis of Epstein-Barr virus-positive (EBV+) mature T-cell and natural killer (NK)-cell neoplasms is challenging to understand. The clinical features are diverse, with no typical manifestation. Therefore, it is important to analyze the association of the clinical characteristics and prognoses of patients with various factors associated with EBV+ T/NK-cell neoplasms, particularly extra...

Background: Hypocholesterolemia possibly due to increased demand and uptake is correlated with elevated cancer risk mortality. However, hardly any current prognostic factor or model for chronic lymphocytic leukemia (CLL) established on reprogramed lipid metabolism, which suggests the importance of nutritional status tumor metabolism during leukemogenesis has been neglected. Our study aims inves...

We follow a new paradigm of programming languages in which imperative programming constructs and programming abstractions are built around a declarative query language. Seamless integration of queries with programming constructs implies a new approach to query languages, in which we employ the classical naming, scoping and binding issues. We de ne a simple abstract storage model, which makes po...

Non-Hodgkin’s lymphomas (NHL) are a heterogeneous group of lymphoproliferative disorders. Diffuse large B-Cell Lymphoma (DLBCL) is the most common NHL in adults, it accounts around 30-40% all NHL. Chemoimmunotherapy regimen based on Rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) standard care for DLBCL patients. The present study investigated its application real-...

Despite the promising introduction of the proteasome inhibitor bortezomib in the treatment of mantle cell lymphoma (MCL), not all patients respond, and resistance often appears after initial treatment. By analyzing a set of 18 MCL samples, including cell lines with constitutive or induced resistance to bortezomib, we found a high correlation between loss of sensitivity to the proteasome inhibit...