We report that neuronal overexpression of the endogenous inhibitor of calpains, calpastatin (CAST), in a mouse model of human Alzheimer's disease (AD) β-amyloidosis, the APP23 mouse, reduces β-amyloid (Aβ) pathology and Aβ levels when comparing aged, double transgenic (tg) APP23/CAST with APP23 mice. Concurrent with Aβ plaque deposition, aged APP23/CAST mice show a decrease in the steady-state ...

This paper presents a novel approach for the investment planning of virtual power plant trading energy in an electricity market. The comprises conventional generating units, renewable storage and set flexible demands. In order to maximize its expected profit, has possibility installing new conventional, renewable, units. Such decisions are made under long-term uncertainty associated with future...

Abstract This work revisits the R&D duopoly à la (d’Aspremont and Jacquemin, Am Econ Rev 78:1133–1137, 1988, d’Aspremont 80:641–642, 1990) (AJ henceforth) considering an economy with firms engaged in corporate social responsibility (CSR). In traditional AJ setting without spill-over effects, invest as a sub-game perfect Nash equilibrium (SPNE) strategy, but they are cast into prisoner’s dil...

subluxation of the proximal interphalangeal joint (pipj or pastern joint) is an uncommon condition that occurs in the forelimb or hindlimb. thoroughbred racehorses rarely show dorsal pastern subluxation (thoroughbred ringbone) secondarily to an injury to the soft tissues supporting the fetlock. a 4-year-old thoroughbred mare was presented with signs of lameness, swelling of the dorsal aspect of...

background: creating a socket with proper fit is an important factor to ensure the comfort and control of prosthetic devices. several techniques are commonly used to cast transtibial stumps but their effect on stump shape deformation is not well understood. this study compares the dimensions, circumferences and volumes of the positive casts and also the socket comfort between two casting method...

CSF fistula/CSF leak is a pathological disorder that spans all ages. the primary clinical characteristic of this disorder is abnormal leakage of cerebrospinal fluid (CSF), from CSF containing compartments of the central nervous system (CNS) to the around space due to abnormal defect of the Dura matter and the skull [1], which typically appears as a clear watery leakage from nose (rhinorrhea) or...

A MAP holds the corners M icrotubule-associated proteins (MAPs) reinforce microtubules (MTs). Fourniol et al. provide the fi rst close-up of a MT-bound MAP, clarifying how it adds stability. The building blocks of MTs are dimers of one and one -tubulin subunit. These dimers line up end to end to build protofi laments, which in turn align side by side in a ring shape to form a hollow MT. MAPs he...

Shadows are everywhere, but they usually go unnoticed. We do, however, use their consequences all the time. Figure 1A shows two pictures each with a green square in front of a checkerboard background. The two pictures differ only in the cast shadows of the square. Because of these differences, the right square appears to be further from the background than the left square. By adding motion to t...

Appearance-based approaches have the advantage of representing the variability of an object’s appearance due to illumination change without explicit shape modeling. While a substantial amount of research has been performed on the representation of object’s diffuse and specular shading, little attention has been paid to cast shadows which are critical for attaining realism when multiple objects ...

We consider communication protocols for N -way all-cast relay networks, which comprise N source terminals such that each source terminal demands messages from all other source terminals with the help of a relay. The derived protocols are characterized by the fact that physical layer network coding is employed at the relay, where each source has side information about the signals it has sent. Am...