Cervical cancer is the second most common cause of cancer-related deaths in women worldwide. Screening for cervical cancer is accomplished utilizing a Pap smear and pelvic exam. While this technology is widely available and has reduced cervical cancer incidence in industrialized nations, it is not readily available in third world countries in which cervical cancer incidence and mortality is hig...

abstract background: cervical cancer is the most common female genital tract malignancy and is the major cause of death from gynecologic cancer worldwide. the majority of cervical cancers develop through a series of gradual, precancerous lesions. screening asymptomatic women with regular pap smears allows diagnosis of the readily treatable preinvasive phase. we performed this study to determine...

BACKGROUND Human papillomavirus (HPV) is believed to be the most important cause of cervical cancer. Recent studies suggest that long duration use of oral contraceptives increases the risk of cervical cancer in HPV positive women. METHODS Results from published studies were combined to examine the relationship between invasive and in situ cervical cancer and duration and recency of use of hor...

Accessible online at: www.karger.com/ort Fax +49 761 4 52 07 14 [email protected] www.karger.com Benefits and Risks of Cervical Cancer Screening The mechanism of secondary cancer prevention is based on the detection of precursor lesions that are surgically excised. Hereby, the natural cycle of carcinogenesis is interrupted, and development of cervical cancer is prevented actively. In the c...

BACKGROUND Worldwide cervical cancer remains a leading cause of mortality from gynecologic malignancies. The link between cervical cancer and persistent infection with HPV has been established. At a molecular level little is known about the transition from the precancerous state to invasive cancer. To elucidate this process, cervical biopsies from human specimens were obtained from precancerous...

Introduction: Cervical cancer is the third most common cancer among women and is more common in developing countries such as India, due to lack of good screening tests. The efficacy of the Pap smear is hampered by high inter-observer variability and high false positive and false negative rates. Liquid based cytology has not been shown to improve sensitivity or specificity when compared to Pap s...

AIM AND BACKGROUND Cervical cancer is the second most common cancer in European women aged 15-44 years. The aim of this study was to estimate the direct cost of managing invasive cervical cancer in Italy. METHODS Data from the Italian Network of Cancer Registries were used to estimate the annual number of new cervical cancer cases. To assess the management costs, a typical management pathway ...

BACKGROUND The objective of this study was to evaluate the clinical outcomes and to discuss the management of women presenting with an invasive cervical cancer during pregnancy. PATIENTS AND METHODS We retrospectively reviewed patients treated for an invasive cervical cancer diagnosed during pregnancy between 1985 and 2000 in our institution. RESULTS Twenty-one pregnant patients among a tot...

We used an enzyme-linked immunosorbent assay to test sera from 186 cases of invasive cervical cancer and 172 age-matched controls for IgG and IgA antibodies to an human papillomavirus 16 E7 peptide and to peptide 245, representing an epitope in E2. Cases had significantly higher mean absorbance values than controls for both immunoglobulin isotypes to E7 and elevated mean values for IgG to pepti...