Despite the known side effects of liver damage, among other issues, paracetamol (N-acetyl-p-aminophenol) continues to be one of the most commonly used drugs worldwide for conditions such as pain and fever and it is often purchased without medical prescription. It is usually administered as a tablet, but it is also available as solutions, suppositories and intravenous preparations. In addition, ...

Many techniques have been developed to overcome the bioavailability problem of poorly soluble drugs. The nanonization is one in that micronized particle converted nanoparticle. Several processes are applied for nanocrystal production, including precipitation, milling, high pressure homogenization and combination method. formulation administered via various routes like oral, intravenous, intramu...

Occlusive lesions of the main arteries extremities are a common and severe disease that leads to disability has high rate death [1]. Many different drugs known for treatment this pathology, however, despite large number pharmacological conservative methods, surgical methods most effective in terms saving limb [3, 4]. However, therapy continue be important component arterial ischemia, which requ...

Four cases of feline permethrin intoxication are described. The cause of intoxication is the application of canine permethrin spot-on product (Advantix®, Bayer) by the owners. Principal clinical guidelines recommends the use of anticonvulsant drugs to treat seizures or neurological symptoms after initial stabilization and dermal decontamination. The use of lipid emulsion had an increasing inter...

Local Anesthesia is performed via drugs administrated subcutaneously for narcotizing small areas (finger, small skin cuts etc.). With this method, patient relaxation is provided through intravenous relaxing drugs. It is simple, easy to apply and less risky method. It is the best method for managing the pain in small surgical procedures. The patient may be discharged just after the operation. Th...

BACKGROUND The management of ventricular electrical storm can prove to be a challenge for the clinician given its complexity and life threatening consequences. CASE CHARACTERISTICS 8-year-old boy with repeated life-threatening polymorphic ventricular tachycardia following aortic valve replacement surgery. INTERVENTION Defibrillated 45 times in addition to multiple antiarrhythmic drugs. OU...

We present the case of a young man who was transferred to our hospital with worsening acute disseminated encephalomyelitis (ADEM) despite treatment with intravenous methylprednisolone, intravenous immunoglobulin and plasma exchange. He developed neuroleptic malignant syndrome (NMS) without the use of dopamine-modulating drugs. His progressive clinical improvement started after treatment with in...

The effects of slow intravenous infusion of three different respiratory stimulants (dimeftine, nikethamide and prethcamide) on minute and alveolar ventilation, blood gases and pH were studied in 18 patients with chronic pulmonary emphysema and chronic respiratory failure. For a more accurate assessment of the results of the double blind controlled trial, a factorial design in a Youden square sc...

The growing importance of ambulatory surgery during the past decade has led to the development of efficient anesthetic techniques in terms of quality and safety of anesthesia and recovery. In these challenging objectives, intravenous techniques have played an important role, as they provide safe, efficient, and cost-effective anesthesia in the ambulatory setting. Among the numerous intravenous ...

The effects of isoprenaline and salbutamol administered orally, by inhalation, or by intravenous infusion were compared in 13 asthmatic patients. Bronchodilator activity was assessed by serial measurement of specific airways conductance (SGaw). Log-dose response curves were obtained for both drugs and showed them to be equipotent as bronchodilators. Cardiovascular effects were variable, but in ...