Fifteen per cent. of all cases of Rh-isoimmunization end in stillbirth. Until 1963 the only available means of preventing this outcome in cases with a high risk of stillbirth was to deliver the foetus prematurely before intrauterine death had occurred. The value of this was limited, because many intrauterine deaths due to haemolytic disease of the newborn occur early in pregnancy, and because i...

Although volvulus is mostly seen in infancy, rare cases of intrauterine have also been reported. Fetal ultrasonographic (USG) examination a 32-year-old woman at the 24th gestational week, showed focal dilatation intestines with an increased wall echogenity dilated segments. At subsequent visits USG revealed progressive intestines. The patient presented preterm labor 32nd week. Cullen's sign dev...

Development of the kidney can be altered in utero in response to a suboptimal environment. The intrarenal factors that have been most well characterized as being sensitive to programming events are kidney mass/nephron endowment, the renin-angiotensin system, tubular sodium handling, and the renal sympathetic nerves. Newborns that have been subjected to an adverse intrauterine environment may th...

Since the first mention of fetal programming of adult health and disease, a plethora of programming events in early life has been suggested. These have included intrauterine and postnatal events, but limited attention has been given to the potential contribution of the birth process to normal physiology and long-term health. Over the last 30 years a growing number of studies have demonstrated t...

Human and animal studies show that suboptimal intrauterine environments lead to fetal programming, predisposing offspring to disease in later life. Maternal obesity has been shown to program offspring for cardiovascular disease (CVD), diabetes, and obesity. MicroRNAs (miRNAs) are small, noncoding RNA molecules that act as key regulators of numerous cellular processes. Compelling evidence links ...

Intrauterine and perinatal life are critical periods for programming of cardiometabolic diseases. However, their relative role remains controversial. We aimed to assess, at weaning, sex-dependent alterations induced by fetal or postnatal nutritional interventions on key organs for metabolic and cardiovascular control. Fetal undernutrition was induced by dam food restriction (50 % from mid-gesta...