Objective: To determine the perinatal outcome of intrahepatic cholestasis pregnancy and its association with obstetric biochemical parameters.
 Study Design: cross-sectional study.
 Place Duration Study: Pak Emirates Military Hospital, Rawalpindi, from Feb to Aug 2020.
 Methodology: Among 3201 patients, 50 patients were included in study. Data was collected on a well-designed pro...

Background: Pregnancy is an opportunity to adopt favorable health behaviors. We studied whether intrahepatic cholestasis of pregnancy (ICP) promotes favorable health behavior in later life. Design: A prospective controlled cohort study. The method was a questionnaire survey in 2010 among 575 women with ICP and 1374 controls, all having delivered between the years 1969 and 1988 in Tampere Univer...

Citrullinemia is the earliest identifiable biochemical abnormality in 13 neonates with intrahepatic cholestasis due to a citrin deficiency (NICCD) and it has 14 been included in newborn screening panels using tandem mass spectrometry. 15 However, only one neonate was positive among 600,000 infants born in Sapporo 16 city and Hokkaido, Japan between 2006 and 2017. We investigated 12 neonates wit...

A 44-year-old man developed severe pruritus with jaundice which subsequently proved fatal. Liver histology showed intense cholestasis, but at postmorten the bile ducts were patent and there was no cirrhosis, the findings being consistent with a cholestatic drug reaction. The most likely precipitant was the benzodiazepine triazolam, and surveillance is indicated for any further reactions to this...

Neonatal cholestasis is a prolonged elevation of the serum levels of conjugated bilirubin beyond the first 14 days of life. Commonest etiologies include extrahepatic conditions like biliary atresia, intrahepatic like congenital malformations, infections and inborn errors of metabolism. TORCH infections constitute 22% cases of neonatal hepatitis, of which Cytomegalovirus is the commonest agent. ...

Cholestasis may be defined as stagnation of bile within the intrahepatic or extrahepatic biliary tree. Biochemically, there is retention of conjugated bilirubin, bile salts, and alkaline phosphatase; morphologically, there is at least dilatation of biliary canaliculi and loss of their microvilli, and later accumulation of bile pigment in the canaliculi (bile plugs)."0 The mechanism underlying t...

SINCE the report of Laurell and Eriksson in 1963, in which they showed an increased frequency of emphysema in individuals with alpha-1-antitrypsin deficiency, this combination has been described by numerous authors. Eriksson (1965) mentioned that some of the emphysematic patients had cirrhosis of the liver. This was also found by others (Thuesen Pedersen, Weeke and Georg, 1969), but was initial...

Hodgkin’s Disease (HD) is a neoplasia with bimodal peak at age 20-30 years and after age of 75. As it is well known as a young people disease it’s not rare to diagnose HD in pregnant women. Its incidence in pregnant population is estimated to be 1 per 34000 live births. Several studies have shown that pregnancy doesn’t get worsen the prognosis of disease. Presentation as cholestatic febrile ill...