Background and Purpose In this study we investigated whether cerebrospinal fluid in patients with brain infarction possesses an activity that contributes to the evolution of brain ischemia. As a test, the effect of cerebrospinal fluid on Ca influx into the intracellular space was chosen because this process is a mechanism for vasospasm, platelet aggregation as thrombi, and neuron damage. Method...

Neurokinin A (NKA) evokes salivary secretion. Despite such reports, the direct effect of NKA on salivary secreteion in submandibular gland has not been clarified. Here we studied characterization of salivary fluid secretion induced by NKA in the perfused submandibular grand (SMG) of the rat. NKA (3-100 nM) stimulated salivary fluid secretion in a dose-dependent manner. The profile of secretion ...

During exercise in the heat, sweat output often exceeds water intake, resulting in hypohydration, which is defined as a body fluid deficit. This fluid deficit is comprised of water loss from both the intracellular and extracellular fluid compartments. Hypohydration during exercise causes a greater heat storage and reduces endurance in comparison with euhydration levels. The greater heat storage...

Hyperkalemia is a common electrolyte abnormality frequently complicated with chronic kidney disease. By injecting potassium chloride (KCl) solutions intravenously into bullfrogs, we reproduced typical electrocardiogram (ECG) abnormalities of hyperkalemia in the frog hearts, such as peaked T waves and widening QRS complexes. Simultaneous recordings cardiac action potentials showed morphological ...

Otitis media (OM), middle ear infection, represents a significant burden on children, their families, and the healthcare system. OM is major cause of hearing loss in children if left untreated who suffer chronic recurrent forms OM, this disease can have serious life-long sequelae. Chronic are recalcitrant to current therapies due formation biofilms intracellular biofilm pods by otopathogens muc...

Potassium-sensitive microelectrodes were used to measure the intracellular level of potassium in Calliphora salivary glands. During stimulation with 1 X 10(-8) M 5-HT, the potassium concentration increased from a resting level of 133.2 to 139.0 mM. When the external concentration of potassium was reduced below 2mM there was a rapid loss of potassium which could be partially reversed by 5-HT. Du...

BACKGROUND/AIM Fluid volume overload occurs in chronic kidney disease (CKD), leading to the compensatory release of natriuretic peptides. However, the elevated cardiac peptides may also be associated with malnutrition as well as volume overload. METHODS Body fluid composition was measured in 147 patients with CKD between 2009 and 2015, and its relationship to brain natriuretic peptide (BNP) l...