Design of Cellular Manufacturing System (CMS) involves four major decisions: Cell formation (CF), Group layout (GL), Group scheduling (Gs) and Resource assignment (RA). These problems should be regarded, concurrently, in order to obtain an optimal solution in a CM environment. However; solving complexity by simultaneous consideration of these problems will be increased. In order to over come th...

To design a group layout of a cellular manufacturing system (CMS) in a dynamic environment, a multi-objective mixed-integer non-linear programming model is developed. The model integrates cell formation, group layout and production planning (PP) as three interrelated decisions involved in the design of a CMS. This paper provides an extensive coverage of important manufacturing features u...

Atezolizumab plus carboplatin-etoposide (ACE) represents the new first-line (1L) standard of care for extended stage (ES) Small Cell Lung Cancer (SCLC) patients (pts). This is a single-center retrospective-prospective translational study aiming at investigating correlation immune cell distribution and their spatial metrics in tumor samples ES SCLC pts receiving ACE as 1L treatment, with respons...

Plant layout design is related to the location of facilities (e.g. machines, departments) in a plant. They are known to greatly impact the system performance. Numerous research works related to facility layout have been published. A few literature reviews exist, but they are not recent or are restricted to certain specific aspects of these layout design. The literature analysis given here is re...

AIMS AND OBJECTIVES In this study we describe the development of a short, easy-to-use questionnaire to measure postoperative recovery and evaluate its content validity and intra-patient reliability. The questionnaire is designed to evaluate the progress of postoperative recovery and the long-term follow-up of possible effects of interventions during recovery. METHODS The study involved four s...

 This paper present unequal-sized facilities layout solutions generated by a genetic search program named LADEGA (Layout Design using a Genetic Algorithm). The generalized quadratic assignment problem requiring pre-determined distance and material flow matrices as the input data and the continuous plane model employing a dynamic distance measure and a material flow matrix are discussed. Computa...

In this paper we present a parallel global routing algorithm for general cell layout. The algorithm applies a hierarchical decomposition strategy that recursively divides routing problems into simple, independent subproblems for parallel processing. The solution of each subproblem is based on integer programming and network flow optimization. The algorithm is implemented on a shared-memory mach...

A facility layout problem is concerned with determining the best position of departments, cells, or machines on the plant. An efficient layout contributes to the overall efficiency of operations. It’s been proved that, when system characteristics change, it can cause a significant increase in material handling cost. Consequently, the efficiency of the current layout decreases or is lost and it ...