This study was designed to investigate the effects of L-arginine (the substrate of endothelium-derived nitric oxide) in human forearm vessels. We examined whether intra-arterial infusion of L-arginine dilated forearm vessels and augmented vasodilatory responses to acetylcholine in young, healthy humans. The left brachial artery was cannulated for drug infusions and direct measurement of arteria...

In the present study, we have attempted to elucidate the effects of the intra-arterial injection of microglia on the global ischemia-induced functional and morphological deficits of hippocampal CA1 neurons. When PKH26-labeled immortalized microglial cells, GMIR1, were injected into the subclavian artery, these exogenous microglia were found to accumulate in the hippocampus at 24 h after ischemi...

The sp leen of miniature swine is a blood storage organ which contracts with intra-arterial injection of epinephrine (and presumably other stressful stimul i) and thus autotransfuses the animal . We recommend the removal of the spleen of miniature swine prior to the use of this anima l for any shock studies . APPROVED: ~~~~~~~~~~~~~~~~~ Colonel , MSC Command ing — ~~~~~~~~~~~~~~~~~~~~~~~ ~~~~~~...

Intra-arterial metabolic radiotherapy (using lipiodol labelled with iodine-131 or rhenium-188) is a therapeutic approach that can be used for the treatment of hepatocellular carcinomas (HCC). We propose a detailed description of the tumoral model using the N1-S1 cell line as well as a technique for intra-arterial injection of radiolabelled lipiodol in order to undertake preclinical studies nece...

OBJECTIVE Intra-arterial injection of Mesobuthus tamulus (BT) venom produces reflex vasosensory responses modulating cardiorespiratory parameters in albino rats. The present study was conducted to understand the role of kinin receptors in modulating vasosensory reflexes evoked by BT venom. MATERIALS AND METHODS In urethane-anesthetized rats, tracheostomy was performed to keep the airway paten...

If given by the intra-arterial route, the immediate effect of the hydrogenated alkaloids of ergot is unpredictable. Vasodilation is obtained in some patients only. However, it was found that in those cases who do not react, the vessels respond more easily to the release of sympathetic tone, proving that, nevertheless, the drug has had an (potential) effect, probably on the neurovascular apparat...

In recent years a number of reports have indi cated that nitrogen mustard exerts a greater effect in certain human neoplasms when admin istered intra-arterially than when given by the conventional route of injection (1, 2, 3, 11-13). Intra-arterial treatment was originally considered of value primarily in neoplasms confined to the extremities or head. Maxfield and his associates have recently t...