Recent evidence suggests that genetic studies may contribute to a better understanding of individual susceptibility to caries. Matrix metalloproteinases (MMPs) and their tissue inhibitors have been suggested to be involved in the caries process. The purpose of this study was to determine if polymorphisms in MMP2 (rs243865), MMP9 (rs17576), MMP13 (rs2252070), and TIMP2 (rs7501477) were associate...

Studies indicate that previous caries experience can influence future caries development; however, caries-free individuals also may develop caries. The aim of this study was to examine the relationship between baseline caries experience and salivary mutans streptococci (SMS) levels as an indicator for predicting caries incidence in pre-school children. One hundred forty-eight preschool children...

Dental caries is an infectious disease which still constitutes a public health concern. It begins at an early age and is caused mainly Streptococcus mutans (S. mutans). The aim of this study was to characterize the salivary humor immune response to S. mutans proteins in patients with caries, with history of caries and without caries, in order to determine which S. mutans proteins participate in...

Dental caries results from altered microbial community activity in disease compared to health. Caries advanced into dentin was compared with coronal caries and caries-free sites. Oral bacterial samples were obtained from young children, placed in RNAlater and stored frozen. mRNAwas purified and sequenced on an Illumina NextSeq 500 platform. Gene sequences were aligned against taxa in HOMD and g...

The advent of "Adhesive Dentistry" has simplified the guidelines for cavity preparation enormously. The design and extent of the current preparations are basically defined by the extent and shape of the caries lesion, potentially slightly extended by bevelling the cavity margins in order to meet the modern concept of minimally invasive dentistry. New caries excavation techniques have been intro...

Various combinations of enamel reduction procedures can be used to create space between teeth, to correct discrepancies between mandibular and maxillary teeth and to correct morphologic anomalies during orthodontic treatment. In particular, acid-enhanced interproximal enamel reduction significantly reduces surface roughness. This article presents a review of the literature on enamel reduction p...

Available evidence indicates that infants, for the most part, acquire their oral flora, in particular Streptococcus mutans, from their mothers. The purpose of this study was to explore the effect of rampant caries in rat dams on subsequent caries activity in their offspring. Rampant caries was induced by surgical desalivation of four dams, and subsequent infection with Streptococcus sobrinus 67...

BACKGROUND Attempts have been made to evaluate the biologic dimension of osseointegrated implants, however, most are histologic studies in animals, and the effect of soft tissue support from adjacent teeth on the interproximal dimension of the peri-implant mucosa for anterior single implants has not been addressed. This study clinically evaluated the dimensions of the peri-implant mucosa around...

OBJECTIVES The concept of Cervical Margin Relocation (CMR) consists on placing a base layer of direct resin composite to elevate supra-gingivally the proximal indirect bonded restorations. The aims of this clinical study were to evaluate 1. Bleeding on Probing (BoP) on posterior indirect restorations with one interproximal margin relocated cervically, and 2. possible correlation between depth o...

OBJECTIVE The aim of this controlled clinical trial was to evaluate the effect of topically applied povidone-iodine (PVP-I) used as an adjunct to non-surgical treatment of interproximal class II furcation involvements. MATERIAL AND METHODS Thirty-two patients presenting at least one interproximal class II furcation involvement that bled on probing with probing pocket depth (PPD) ≥ 5 mm were r...