Annulate lamellae are cytoplasmic organelles composed of stacked sheets of membrane containing pores that are structurally indistinguishable from nuclear pores. The functions of annulate lamellae are not well understood. Although they may be found in virtually any eucaryotic cell, they occur most commonly in transformed and embryonic tissues. In Drosophila, annulate lamellae are found in the sy...

Jones et al., 2021Jones R. Bragagnolo G. Arranz Reguera J. Capping pores of alphavirus nsP1 gate membranous viral replication factories.Nature. 2021; 589: 615-619Crossref PubMed Scopus (18) Google Scholar and Zhang 2021Zhang K. Law Y.-S. M.C.Y. Tan Y.B. Wirawan M. Luo D. Structural insights into the RNA capping plasma membrane targeting by Chikungunya virus nonstructural protein 1.Cell Host Mic...

Glutamate receptors are ligand-gated ion channels that mediate fast excitatory synaptic transmission throughout the central nervous system. Functional receptors are homo- or heteromeric tetramers with each subunit contributing a re-entrant pore loop that dips into the membrane from the cytoplasmic side. The pore loops form a narrow constriction near their apex with a wide vestibule toward the c...

JCB • VOLUME 167 • NUMBER 6 • 2004 994 Opening closed pores closed mitosis may be less closed than was thought, based on results from Colin De Souza, Stephen Osmani, and colleagues (The Ohio State University, Columbus, OH). The authors find that a fungus opens nuclear pores during mitosis to permit diffusion into and out of the nucleus. Simple organisms may thus be viable model systems for the ...

Address correspondence to Shoichiro Tsukita, M.D., Ph.D., Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan. Tel.: 81-75-753-4372. Fax: 81-75-753-4660. E-mail:htsukita @mfour.med.kyoto-u.ac.jp 1 Abbreviations used in this paper: CPE, Clostridium perfringens enterotoxin; TJ, tight junction. In vertebrates, tight junctions (TJs) 1 play a central ro...