In vivo release profiles of drug-loaded biodegradable implants were noninvasively monitored and characterized using X-ray computed tomography (CT). The imaging method was adapted and optimized to quantitatively examine the release of an active agent from a model cylindrical PLGA device (the millirod) into rabbit livers over 48 h. Iohexol, a CT contrast agent, served as a model drug; optimizatio...

The threat of bioterrorism and the possibility of accidental release have spawned a growth of interest in modeling the course of the release of a highly pathogenic agent. Studies focused on strategies to contain local outbreaks after their detection show that timely interventions with vaccination and contact tracing are able to halt transmission. However, such studies do not consider the effect...

Previous investigators using the extent of uptake of the weak base methylamine to measure internal pH have shown that the pH in the core region of dormant spores of Bacillus megaterium is 6.3 to 6.5. Elevation of the internal pH of spores by 1.6 U had no significant effect on their degree of dormancy or their heat or ultraviolet light resistance. Surprisingly, the rate of methylamine uptake int...

Commitments are being used widely to specify interaction among autonomous agents in multiagent systems. While various formalizations for commitments and its life cycle exist, there has been little work that studies commitments in relation to each other. However, in many situations, the content and state of one commitment may render another commitment useless or even worse create conflicts. This...

Hydrophilic polymers alone are not quite efficient in controlling the release of highly water soluble drugs. Hydrophobic Polymer and pore forming agent have been extensively investigated for sustaining the release of drug. They provide several advantages include good stability at varying pH ranges and effectively retards the water soluble drug. In the present study it was a novel approach where...

The main goal of this research was to compare the in vitro release rates of nano- and microcapsules of Silybum marianum extract (SME) in animal simulated gastric and intestinal medium conditions. The extract was encapsulated within sodium alginate carriers using emulsification/internal gelation method. Particle size, zeta potential, polydispersity index (PDI) and morphology of...

A large number of factors associated with the agent and habitat can be manipulated when making a biocontrol release. Yet, it is only recently that an experimental approach has been taken, particularly with the release of arthropod weed biocontrol agents, for example examining factors such as release size to test ideas originating from theoretical or retrospective studies. For release size, both...

The present research work aimed to formulate and evaluate a gastro retentive in situ gelling system of Nicardipine Hydrochloride using Sodium Alginate as polymer, HPMC K100M release retard calcium carbonate cross-linking agent, tri-sodium citrate fluidity enhancer agent treat hypertension. mechanism for the floatation was based on ionic cross-linking. Several evaluation tests were carried out p...

Abstract Aiming at the problem that equipment maintenance support system is difficult to describe with highly stylized mathematical model, a framework model of agent constructed. The paper introduces Agent modeling method, analyzes structure and workflow system, abstracts according guarantee characteristics Agent. internal modules each are designed agents designed. task environment between them...