Mouse cells carrying the dominant resistance gene Mx develop a more efficient antiviral state toward influenza viruses in response to interferon than do Mx-negative cells. We have identified an Mx gene-associated product by labeling cultured peritoneal macrophages and embryonic cells with [35S]methionine in the presence or absence of interferon. The radioactive proteins from unfractionated cyto...

Human papillomaviruses (HPVs) infect keratinocytes and induce proliferative lesions. In infected cells, viral gene products alter the activities of cellular proteins, such as Rb and p53, resulting in altered cell cycle response. It is likely that HPV gene products also alter expression of cellular genes. In this study we used microarray analysis to examine the global changes in gene expression ...

CLINICAL INTERmNTION AND THERAPEUTIC TRLALS The Effect of a-Interferon on Bone Marrow Megakaryocytes and Platelet Production Rate in Essential Thrombocythemia .................. H. Wadenvik, J. Kutti, B. Ridell, P. Revesz, S. Jacobsson, B. Magnumon, J. Westin, and L. El& Combined Therapy With Recombinant Granulocyte Colony-Stimulating Factor and Erythropoietin Decreases Hematologic Toxicity Fro...

Background and Objectives. Autologous stem cell transplantation is a therapeutic option for chronic myeloid leukemia (CML) patients who are not candidates for allogeneic transplant. To reduce the risk of post-autografting disease recurrence, different strategies of stem cell selection have been attempted. The results of using recombinant human granulocyte colony-stimulating factor (rHuG-CSF) fo...

Introduction Cluster of Differentiation 64 (CD64) antigen is a membrane glycoprotein expressed on monocytes and macrophages. It is the high affinity neutrophil FcgRI receptor which is weakly expressed by neutrophils at physiological levels, but strongly upregulated within 4-6 hours by the pleiotropic cytokines such as Interferon-g (IFN-g) and Granulocyte Colony Stimulating Factor (G-CSF) which ...

Submit Manuscript | http://medcraveonline.com Abbreviations: ADCC: Antibody Dependent Cell Mediated Cytotoxicity; CDC: Complement Dependent Cytotoxicity; CTL: Cytotoxic T lymphocyte; DC: Dendritic Cell; GM-CSF: GranulocyteMacrophage Colony Stimulating Factor; HPV: Human Papilloma Virus; HBV: Hepatitis B Virus; IL-2: Interleukin 2; IL-12: Interleukin 12; IFN: Interferon; MHC: Major Histocompatib...

We identify novel mechanisms whereby chemoresistance enables cancer stem cells to create pro-inflammatory tumor microenvironments. Chemoresistant cancer stem cells promote M2 macrophage differentiation through interferon-regulatory factor-5 (IRF5)- and macrophage-colony stimulating factor (M-CSF)-dependent mechanisms and produce various other cell-signaling factors that together fuel inflammati...