نتایج جستجو برای: interferon gamma ifn γ

تعداد نتایج: 231743  

2015
Daniel P. Beiting Shinya Hidano Julie E. Baggs Jeanne M. Geskes Qun Fang E. John Wherry Christopher A. Hunter David S. Roos Sara Cherry Herbert Virgin

The protozoan parasite, Toxoplasma, like many intracellular pathogens, suppresses interferon gamma (IFN-γ)-induced signal transducer and activator of transcription 1 (STAT1) activity. We exploited this well-defined host-pathogen interaction as the basis for a high-throughput screen, identifying nine transcription factors that enhance STAT1 function in the nucleus, including the orphan nuclear h...

Journal: :Chemical communications 2015
Sheng Lin Bingyong He Chao Yang Chung-Hang Leung Jean-Louis Mergny Dik-Lung Ma

In this study, we synthesized a series of 9 luminescent iridium(III) complexes and studied their ability to function as luminescent probes for G-quadruplex DNA. The iridium(III) complex 8 [Ir(pbtz)2(dtbpy)]PF6 (where pbtz = 2-phenylbenzo[d]thiazole; dtbpy = 4,4'-di-tert-butyl-2,2'-bipyridine) showed high selectivity for G-quadruplex DNA over single-stranded and double-stranded DNA, and was subs...

Journal: :Canadian journal of physiology and pharmacology 2016
Ding Yuan Qin Yuan Qianqian Cui Chaoqi Liu Zhiyong Zhou Haixia Zhao Yaoyan Dun Ting Wang Changcheng Zhang

The adjuvant effect of ginsenoside Rg1 on immune responses against hepatitis B surface antigen (HBsAg) in mice was investigated. Female BALB/c mice were subcutaneously injected with saline or HBsAg antigen with or without Rg1 on days 7 and 21. Samples were collected 2 weeks after the boosting for the detection of anti-HBsAg immunoglobulin G (IgG) isotypes in sera and gamma interferon (IFN-γ) an...

2013
Peter E. Kima Lynn Soong

Leishmaniasis is a complex disease that is caused by parasites of the Leishmania genus. Leishmania are further classified into several complexes, each of which can engage in distinct interactions with mammalian hosts resulting in differing disease presentations. It is therefore not unexpected that host immune responses to Leishmania are variable. The induction of interferon gamma (IFN-γ) and re...

Journal: :jundishapur journal of microbiology 0
abdolhossein dalimi parasitology department, faculty of medical sciences faculty, tarbiat modares university, tehran, ir iran; abdolhossein dalimi dvm, phd, professor, department of parasitology, faculty of medical sciences, tarbiat modares university, p.o.box:14155-331, tehran, ir iran vahid nasiri parasitology department, razi vaccine and serum research institute, karaj, ir iran

conclusions in conclusion, pegfp-kmp-gp96 (fusion) induced th1 platform immune response against leishmania major (mrho/ir/75/er) infection. results according to the results, the level of cytokines interferon-gamma (ifn-γ) and interleukin (il)-4, and ratio of ifn-γ /il4 was changed among different groups of mice before and seven weeks after immunization. the cytokines were increased significantl...

2010
Catherine M Worsley Melinda S Suchard Wendy S Stevens Annelies Van Rie David M Murdoch

BACKGROUND Immune reconstitution inflammatory syndrome (IRIS) is an important complication of HAART in sub-Saharan Africa, where opportunistic infections (OIs) including mycobacteria and cryptococcus are common. The immune system's role in HIV infected patients is complex with cytokine expression strongly influencing HIV infection and replication. METHODS We determined the expression patterns...

2012
Azadeh Hosseini-Tabatabaei Reza Baradar Jalili Yunyuan Li Ruhangiz T. Kilani Alireza Moeen Rezakhanlou Aziz Ghahary

Indoleamine 2,3-dioxygenase (IDO) can locally suppress T cell-mediated immune responses. It has been shown that defective self-tolerance in early prediabetic female non-obese diabetic (NOD) mice can be attributed to the impaired interferon-gamma (IFN-γ)- induced IDO expression in dendritic cells of these animals. As IFN-γ can induce IDO in both dendritic cells and fibroblasts, we asked the ques...

2016
Séverine Carrère-Kremer Pierre-Alain Rubbo Amandine Pisoni Sophie Bendriss Grégory Marin Marianne Peries Karine Bolloré Dominique Terru Sylvain Godreuil Arnaud Bourdin Philippe Van de Perre Edouard Tuaillon

Interferon gamma (IFN-γ) release assays (IGRAs) detect Mycobacterium tuberculosis (Mtb) infection regardless of the active (ATB) or latent (LTBI) forms of tuberculosis (TB). In this study, Mtb-specific T cell response against region of deletion 1 (RD1) antigens were explored by a microbead multiplex assay performed in T-SPOT TB assay (T-SPOT) supernatants from 35 patients with ATB and 115 patie...

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