results the frequencies of the aa, at, and tt genotypes were 31%, 51%, and 18% in the chronic hbv patient group, and 40%, 45%, and 15% in the healthy control group, respectively. however, a lack of association of the + 874 polymorphism in the ifn-γ gene of those with chronic hbv infection was found. evaluation of hbv association with this polymorphism was significant under the dominant genetic ...

it is now well documented that interferon gamma (ifn-γ) is the indispensable cytokine for inducing protective immunity against experimental and human cutaneous leishmaniaisis. the importance of ifn-γ receptor (ifn-γr) has also been studied. in the present study, we made attempts to find out whether l. major infection is able to alter the expression of ifn-γr in vivo. in addition, we studied the...

objective(s):experimental allergic encephalomyelitis (eae) is an autoimmune disease validated as animal model of multiple sclerosis (ms). administration of genistein, a phytoestrogenic component of soy, to mice at the onset of eae is known to attenuate the clinical signs of the disease. the potential effects of genistein on established eae is less studied. in the current study, we aimed to comp...

background: hepatitis-c infection is a major problem in chronically transfused patients. we compared interferon-α (inf-α) monotherapy with combination of inf-α and amantadine in the treatment of β-thalassemia major patients who were chronically infected with hcv.materials and methods: forty six thalassemia major patients who were chronically infected with hcv were randomly divided into two grou...

polymorphisms in the β subunit of the high affinity receptor for ige (fcεriβ) and interferon-γ (ifn-γ) genes may influence the risk of asthma. however, the results in asian population are still debatable. we performed a meta-analysis to ascertain the association between the fcεriβ e237g, fcεriβ -109c/t, and ifn-γ 874t/a polymorphisms and asthma in an asian population. databases including pubmed...

background:  multiple  sclerosis  (ms) patients permanently confronted  with serious challenges from treatment regimen. developing  a new  questionnaire in ms management, through  evaluation  of patients’ perspectives   and  knowledge   regarding   treatment  will help  to  identify the  sources  of tension, and  to  build  a therapeutic   alliance.   we   purposed   to   describe    ms patient...

patients and methods this cross - sectional study was conducted on 143 thalassemic patients with chronic hepatitis c, who were treated with a combination of peg-ifn and rbv regimen. the rs12979860 and rs8099917 polymorphisms were assessed as the most common polymorphisms near the il28b gene by the polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp) method. objectives w...

background macrophages play critical roles in innate immune response in the liver. whether macrophages participate in liver innate immunity against hcv replication is poorly understood objectives the aim of this study was to investigate the role of macrophages in liver innate immunity against hcv replication. conclusions macrophages may play an important role in liver innate immunity against hc...

Herpes genitalis is an infection associated with considerable morbidity. Acyclovir, though effective, must be taken daily to prevent recurrences. The effects of interferon on this infection were therefore investigated. In a randomised double blind study, 31 patients with first episodes of genital herpes infection were studied to assess the effect of interferon on the presenting episode and on r...

The molecular size of poly I.poly C required for lysis of interferon-treated L cells was the same as the size required for induction of interferon in these cells. The size requirement for both interferon induction and toxicity for interferon-treated L cells resided in the poly I strand, while variations of the poly C strand size were without effect on interferon induction or cell lysis. The siz...